38933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 784692..786241 Replicon chromosome
Accession NZ_AP024610
Organism Shewanella algae strain TUM4442

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5626_RS03615 Protein ID WP_221052588.1
Coordinates 784692..785993 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5626_RS03620 Protein ID WP_221052589.1
Coordinates 785993..786241 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5626_RS03600 (TUM4442_06990) 780192..780776 + 585 WP_117200305.1 LysE family translocator -
K5626_RS03605 (TUM4442_07000) 780854..782881 - 2028 WP_144438980.1 S9 family peptidase -
K5626_RS03610 (TUM4442_07010) 783185..784552 + 1368 WP_101060124.1 L-cystine transporter -
K5626_RS03615 (TUM4442_07020) 784692..785993 - 1302 WP_221052588.1 type II toxin-antitoxin system HipA family toxin Toxin
K5626_RS03620 (TUM4442_07030) 785993..786241 - 249 WP_221052589.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K5626_RS03625 (TUM4442_07040) 786754..788445 + 1692 WP_221052590.1 ATP-binding cassette domain-containing protein -
K5626_RS03630 (TUM4442_07050) 788458..788832 - 375 WP_014386412.1 PH domain-containing protein -
K5626_RS03635 (TUM4442_07060) 788843..790768 - 1926 WP_221052591.1 U32 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48582.36 Da        Isoelectric Point: 9.5375

>T38933 WP_221052588.1 NZ_AP024610:c785993-784692 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPPITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQANATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMKLLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPENISNSIFENAKKTIKKI

Download         Length: 1302 bp

>T38933 NZ_AP024610:c785993-784692 [Shewanella algae]
ATGCAAAAGCTAATAGCATACATGAATGGTGAACTTGTTGGCACCTTGGCGAAGCATAAGAACGGCGCCCACACTTTTCA
ATATGATAAGGACTGGATAACCAATGCAATGGCTCGCCCACTGTCATTGTCTTTGAGGCTTCAATTACCACCTATTACTT
CCGATGCCGTTATCAACTATTTTGACAACCTCTTACCAGACAGCCCACAAGTCAGAGATAGGATCGTTGCAAGGTACAAA
GCCTCGTCCAAACAACCATTTGATCTTTTGAAAGAAATTGGAAAGGATAGTGTTGGTGCTATTGCACTATTTCCTCCCGA
ACACCCCTATAAAAAAGAGCCGCTCAGCTACGAAATATTGGATAACAAGAAACTAGAAGCCGTTCTTTCTGCATACAAGT
CTGATATTCCCCTCGGAATGCTCAAAGAGGAAGAAGACTTTAGGATCTCAGTGGCAGGTGCTCAAGAAAAAACCGCACTC
TTATTCATTGATGGACAATGGTGTATACCGAAAGGAAACACCCCAACCACTCACATTATCAAGCTGCCAATAGGCGAAAT
ACCACAAGCTAACGCGACCCTGGATCTCAAAGATAGCGTAGAAAATGAATATCTTTGCATTGAGCTAGCTAAAGCGCTGG
GATTCGCAGTTCCCAGCGTCAATATAATCAAAACTGACAACCTTAAAGCTTTAGCTGTAGAACGATTTGATCGACGTTGG
ACAAAAGACAGAGCAGGCTTGCTACGCTTACCTCAAGAAGATATTTGCCAGGTGTTTGGTATGCCATCATCCATCAAATA
TGAATCTCAAGGTGGCCCAGGCATAGCACAGATCATGAAGTTATTAATGGGCTCAAGTAATGCACTTGAAGATCGATATA
ACTTCATGAGATTCCAGGTATTTCAATGGATCATTGGGGCTACGGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AGAGGAGGTAGCTATCGACTCACTCCATTCTACGACATTCTGTCGGCCTACCCATTACTTGGAGGAAAAGGACTCAATAT
TAGACAACTTAAGCTCGCAATGGGATTAAAAGCCACAAAAGGCAAGAAGTATGAAATCAATAAAATCCTGCCTCGTCACT
TTTTAGATACTGCTAAAGCTGTGAATTTTAGTCAGGATAAGATGCAAAGAATAATGGATGAAATGAAAGGTGCGTTACCT
GAGGCAATCTCGCAAGTAAGGGCGAATCTACCAGAGGGCTTTCCAGAGAATATCTCCAACTCTATTTTTGAGAATGCCAA
GAAAACAATTAAAAAAATCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9350.66 Da        Isoelectric Point: 6.2564

>AT38933 WP_221052589.1 NZ_AP024610:c786241-785993 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQPTSPSENDDE
SW

Download         Length: 249 bp

>AT38933 NZ_AP024610:c786241-785993 [Shewanella algae]
ATGATATATAGTCCAAAGCAACTCGCAGATATGATGCTACTGATACGCCAAAAGAATGGCTGGACTCAGTCAGAGTTGGC
GAAAAAAGTCGGTATAAAGCAAGCAACAATCTCGAACTTCGAGAACAACCCCAACAAAACAACGCTTTCTACCTTCTTTA
AGCTTGTACAAGCTATGGATCTAACACTGAGTATCCAAGAAAAAACACAGCCGACTTCGCCAAGTGAAAATGATGATGAG
AGTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References