Detailed information of TA system TA038931

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 1292552..1293194
• Replicon: chromosome
• Accession: NZ_AP024609
• Organism: Shewanella algae strain ATCC 49138

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: -
• Locus tag: K5625_RS05845
• Protein ID: WP_115389948.1
• Coordinates: 1292772..1293194 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5625_RS05840
• Protein ID: WP_028779782.1
• Coordinates: 1292552..1292791 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5625_RS05815 (TUM3811_11510)	1288235..1289062	+	828	WP_044734948.1	prolipoprotein diacylglyceryl transferase	-
K5625_RS05820 (TUM3811_11520)	1289062..1289856	+	795	WP_044734947.1	thymidylate synthase	-
K5625_RS05825 (TUM3811_11530)	1289973..1291148	+	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5625_RS05830 (TUM3811_11540)	1291145..1291528	+	384	WP_062793820.1	hypothetical protein	-
K5625_RS05835 (TUM3811_11550)	1291545..1292453	+	909	WP_115389947.1	transcriptional activator NhaR	-
K5625_RS05840 (TUM3811_11560)	1292552..1292791	+	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5625_RS05845 (TUM3811_11570)	1292772..1293194	+	423	WP_115389948.1	protein YgfX	Toxin
K5625_RS05850 (TUM3811_11580)	1293211..1294821	-	1611	WP_115389949.1	L-aspartate oxidase	-
K5625_RS05855 (TUM3811_11590)	1295020..1295598	+	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5625_RS05860 (TUM3811_11600)	1295623..1296243	+	621	WP_025887842.1	RseA family anti-sigma factor	-
K5625_RS05865 (TUM3811_11610)	1296253..1297185	+	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
K5625_RS05870 (TUM3811_11620)	1297196..1297675	+	480	WP_025010554.1	SoxR reducing system RseC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16318.83 Da
• Isoelectric Point: 7.6045

>T38931 WP_115389948.1 NZ_AP024609:1292772-1293194 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLSFKYLCLLLVLVAFGLALWRLRRWQLCFWLNELGEGQ
FEPGSSFELSGKPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T38931 NZ_AP024609:1292772-1293194 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATCGTTCAAATACTTATGTTTGCTGCTGGTAC
TGGTAGCTTTTGGCCTGGCTCTGTGGCGTTTGCGCCGTTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAAACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCATCTGTGTCGTCTATTGTTGC
AGCGGTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38931 WP_028779782.1 NZ_AP024609:1292552-1292791 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38931 NZ_AP024609:1292552-1292791 [Shewanella algae]
ATGAGTACCCCCAGGGTAAAGTGGGCATGTCGCCGTGGCATGCTGGAGCTTGATGTATTGTTTCAACCTTTTGTGGAGCA
GCATTATGAGACTCTGAGCCCTGAGGACAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGACCCGGAACTGTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1