Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 681795..683335 Replicon chromosome
Accession NZ_AP024609
Organism Shewanella algae strain ATCC 49138

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5625_RS03115 Protein ID WP_208194543.1
Coordinates 682034..683335 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5625_RS03110 Protein ID WP_093982108.1
Coordinates 681795..682031 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5625_RS03080 (TUM3811_06100) 677419..678108 - 690 WP_221051735.1 DUF262 domain-containing protein -
K5625_RS03085 (TUM3811_06110) 678179..678523 - 345 WP_221051736.1 hypothetical protein -
K5625_RS03090 (TUM3811_06120) 678593..679387 - 795 WP_144128538.1 NYN domain-containing protein -
K5625_RS03095 679419..679793 - 375 WP_107110451.1 molecular chaperone DnaJ -
K5625_RS03100 680628..680828 + 201 WP_221051737.1 cold shock domain-containing protein -
K5625_RS03105 (TUM3811_06130) 681002..681586 + 585 WP_221051738.1 cold shock domain-containing protein -
K5625_RS03110 (TUM3811_06140) 681795..682031 + 237 WP_093982108.1 helix-turn-helix domain-containing protein Antitoxin
K5625_RS03115 (TUM3811_06150) 682034..683335 + 1302 WP_208194543.1 HipA domain-containing protein Toxin
K5625_RS03120 (TUM3811_06160) 683396..684349 + 954 WP_159352807.1 tetratricopeptide repeat protein -
K5625_RS03125 (TUM3811_06170) 684454..685089 - 636 WP_115390024.1 peptide chain release factor H -
K5625_RS03130 (TUM3811_06180) 685089..686252 - 1164 WP_115389739.1 RNA ligase RtcB family protein -
K5625_RS03135 (TUM3811_06190) 686638..686985 - 348 WP_115389740.1 hypothetical protein -
K5625_RS03140 (TUM3811_06200) 687321..687755 - 435 WP_020442396.1 HNH endonuclease -
K5625_RS03145 (TUM3811_06210) 687806..688081 - 276 WP_045283442.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48611.40 Da        Isoelectric Point: 4.7041

>T38930 WP_208194543.1 NZ_AP024609:682034-683335 [Shewanella algae]
MSEAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWQQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEEPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGESALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGRHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFITPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIDGVIAMLDGLD
KDEQAFVASYKAQLLARCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T38930 NZ_AP024609:682034-683335 [Shewanella algae]
ATGAGTGAAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGAGTTGTCATTCGATCCCGCCAC
CGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCAGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCCGAAAACAGGGGCTTGGATTATCTCATCGAATCT
CTTGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATAGGCTTGGATACTGCCGGTGCCGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTACGCCTGGAAGAGCCTGAGC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCGAAACTGAATCTGTTCTACAAC
GGTAAGCAATTTGGTTTCGGTGAAAGTGCCTTATCATCGACCCATATCTTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGTCGATAGCCATGAATGTCGCGAATGTTGAGATCCGCCATTTTGGCCGGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAACAGCGGGTGCTGAGAAGGCATATTATCGAT
AGCTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
CGAAGGTGTTAGCCTGCCCAGGCTGTTTGCTCTTGCGGAGCAATGCGCTAATCCGGCGGCGGCCAAACAGGATATGCTGC
AGTGGACTCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATTACACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCTTGTATGAGGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGCCTATCAATTGGCCGCTTTCAGCGAGGATATAGGGTTACCCAGAGCCTTGG
TGAGCAACAGCCTAACCAGAATGGCGACGAGAATAAGCCAAGAAATAGACGGTGTTATCGCAATGCTCGATGGATTGGAT
AAGGATGAGCAGGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGGCAAGGTGTGAGCGCTATTTGGATATTGCGCCCCA
AATCAATGAGATGGAACTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8487.03 Da        Isoelectric Point: 9.6887

>AT38930 WP_093982108.1 NZ_AP024609:681795-682031 [Shewanella algae]
MASPLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIRLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT38930 NZ_AP024609:681795-682031 [Shewanella algae]
ATGGCCTCCCCATTAACTCCACATTCATTGGGCGCTTTAATTAAGGCCCGTAGAAAAGAAGCGGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAAGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGTTTGGGGATCCGTCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References