Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3658870..3659490 Replicon chromosome
Accession NZ_AP024605
Organism Yersinia pseudotuberculosis strain 72344

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag QUD84_RS16420 Protein ID WP_002208622.1
Coordinates 3659287..3659490 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9PQI8
Locus tag QUD84_RS16415 Protein ID WP_025382853.1
Coordinates 3658870..3659238 (+) Length 123 a.a.

Genomic Context

QUD84_RS16400QUD84_RS16405QUD84_RS16410QUD84_RS16415QUD84_RS16420QUD84_RS16430QUD84_RS16435QUD84_RS16445QUD84_RS16440QUD84_RS16450QUD84_RS16455
Location: 3657065..3657325 (261 bp)
Type: Others
Protein ID: WP_002208617.1
Location: 3657341..3657484 (144 bp)
Type: Others
Protein ID: WP_002208618.1
Location: 3658358..3658711 (354 bp)
Type: Others
Protein ID: WP_002208619.1
Location: 3658870..3659238 (369 bp)
Type: Antitoxin
Protein ID: WP_025382853.1
Location: 3659287..3659490 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 3660185..3660382 (198 bp)
Type: Others
Protein ID: WP_230826541.1
Location: 3660396..3660785 (390 bp)
Type: Others
Protein ID: WP_002208623.1
Location: 3661699..3662559 (861 bp)
Type: Others
Protein ID: WP_012105571.1
Location: 3660921..3661442 (522 bp)
Type: Others
Protein ID: WP_011191872.1
Location: 3662819..3664108 (1290 bp)
Type: Others
Protein ID: WP_002228344.1
Location: 3664148..3664486 (339 bp)
Type: Others
Protein ID: WP_002208627.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QUD84_RS16400 (YP72344_31510)3657065..3657325+261WP_002208617.1type B 50S ribosomal protein L31-
QUD84_RS164053657341..3657484+144WP_002208618.1type B 50S ribosomal protein L36-
QUD84_RS16410 (YP72344_31520)3658358..3658711+354WP_002208619.1hypothetical protein-
QUD84_RS16415 (YP72344_31530)3658870..3659238+369WP_025382853.1Hha toxicity modulator TomBAntitoxin
QUD84_RS16420 (YP72344_31540)3659287..3659490+204WP_002208622.1expression modulating protein YmoAToxin
QUD84_RS164303660185..3660382+198WP_230826541.1hypothetical protein-
QUD84_RS16435 (YP72344_31550)3660396..3660785+390WP_002208623.1MGMT family protein-
QUD84_RS16440 (YP72344_31560)3660921..3661442-522WP_011191872.1YbaY family lipoprotein-
QUD84_RS16445 (YP72344_31570)3661699..3662559+861WP_012105571.1acyl-CoA thioesterase II-
QUD84_RS16450 (YP72344_31580)3662819..3664108-1290WP_002228344.1ammonium transporter AmtB-
QUD84_RS16455 (YP72344_31590)3664148..3664486-339WP_002208627.1P-II family nitrogen regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T38927 WP_002208622.1 NZ_AP024605:3659287-3659490 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T38927 NZ_AP024605:3659287-3659490 [Yersinia pseudotuberculosis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCTTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.98 Da        Isoelectric Point: 4.5221

>AT38927 WP_025382853.1 NZ_AP024605:3658870-3659238 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSELSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT38927 NZ_AP024605:3658870-3659238 [Yersinia pseudotuberculosis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCGAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2K5S

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0T9PQI8

References