Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3477829..3478512 Replicon chromosome
Accession NZ_AP024605
Organism Yersinia pseudotuberculosis strain 72344

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag QUD84_RS15585 Protein ID WP_286226865.1
Coordinates 3478192..3478512 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QUD84_RS15580 Protein ID WP_286226863.1
Coordinates 3477829..3478155 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD84_RS15545 3473202..3473837 - 636 WP_286226849.1 inovirus Gp2 family protein -
QUD84_RS15550 (YP72344_29910) 3474420..3474857 + 438 WP_286226851.1 hypothetical protein -
QUD84_RS15555 (YP72344_29920) 3474874..3475677 + 804 WP_286226853.1 hypothetical protein -
QUD84_RS15560 (YP72344_29930) 3475728..3475907 + 180 WP_286226855.1 hypothetical protein -
QUD84_RS15565 (YP72344_29940) 3475943..3476383 + 441 WP_286226857.1 hypothetical protein -
QUD84_RS15570 (YP72344_29950) 3476458..3477279 + 822 WP_057533536.1 DUF932 domain-containing protein -
QUD84_RS15575 (YP72344_29960) 3477346..3477816 + 471 WP_057533535.1 DNA repair protein RadC -
QUD84_RS15580 (YP72344_29970) 3477829..3478155 + 327 WP_286226863.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QUD84_RS15585 (YP72344_29980) 3478192..3478512 + 321 WP_286226865.1 TA system toxin CbtA family protein Toxin
QUD84_RS15590 (YP72344_29990) 3478868..3479377 + 510 Protein_3051 integrase arm-type DNA-binding domain-containing protein -
QUD84_RS15595 (YP72344_30000) 3479447..3479707 + 261 Protein_3052 transposase -
QUD84_RS15600 (YP72344_30010) 3479793..3479978 + 186 WP_050116889.1 hypothetical protein -
QUD84_RS15605 (YP72344_30020) 3480141..3480392 - 252 WP_002212204.1 hypothetical protein -
QUD84_RS15610 (YP72344_30030) 3481103..3481870 + 768 WP_012105497.1 esterase -
QUD84_RS15615 (YP72344_30040) 3482202..3482489 + 288 WP_002212202.1 LexA regulated protein -
QUD84_RS15620 3482649..3482870 + 222 WP_072102224.1 hypothetical protein -
QUD84_RS15625 (YP72344_30050) 3482943..3483470 + 528 WP_002215386.1 flavodoxin FldA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3479447..3479710 263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12011.73 Da        Isoelectric Point: 5.4590

>T38926 WP_286226865.1 NZ_AP024605:3478192-3478512 [Yersinia pseudotuberculosis]
MQISTVPATVPVSPRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAILEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTANDILTARKATGLMHT

Download         Length: 321 bp

>T38926 NZ_AP024605:3478192-3478512 [Yersinia pseudotuberculosis]
ATGCAAATTTCAACTGTACCGGCCACGGTGCCTGTTTCGCCACGCCTGTCGCCCGTCCAGGTATGGCAGCAATTGTTAAC
GTATCTGCTGGAACACCATTACGGCCTCACTCTCAACGACACACCATTCCATGACGATGCAGCAATCCTGGAGCATATCG
AAGCGGGAATAACGCTGGCTGATGCGGTAAATTTCCTTGTGGAACGCTATGAACTGGTACGTATTGACCGAAAGGGATTC
ACCTGGCAGGAACAAACACCTTTTCTTACCGCTAACGATATTCTCACTGCCAGGAAAGCTACCGGATTAATGCACACATA
A

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11867.36 Da        Isoelectric Point: 5.4501

>AT38926 WP_286226863.1 NZ_AP024605:3477829-3478155 [Yersinia pseudotuberculosis]
MPLTPSHDGGLQSDITPRFGARLVQEGNSLHYLTDSAGLTGSFSPEQLQTLEQTFPLLFIAQLENMLRSGELNPGWQHQV
KVHLAGFSCVADTRASFGYVYISIYPAQ

Download         Length: 327 bp

>AT38926 NZ_AP024605:3477829-3478155 [Yersinia pseudotuberculosis]
ATGCCATTAACACCATCCCATGATGGGGGGTTACAAAGCGATATCACCCCAAGATTTGGAGCCAGATTAGTTCAGGAAGG
CAATAGCCTACATTACCTCACTGACAGCGCCGGTTTGACGGGGAGCTTTAGTCCAGAGCAATTACAGACACTGGAACAAA
CTTTCCCTCTGTTGTTTATCGCACAACTGGAAAATATGCTGCGTTCCGGCGAGCTAAATCCTGGTTGGCAACATCAGGTG
AAGGTTCACCTTGCCGGATTCAGCTGTGTAGCTGATACCCGTGCCAGTTTCGGCTACGTTTACATTTCAATTTATCCAGC
ACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References