38911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 793952..795387 Replicon chromosome
Accession NZ_AP024602
Organism Mycoplasma mycoides strain Caprivi

Toxin (Protein)


Gene name abiEii Uniprot ID Q6MU66
Locus tag mmcaprivi_RS03470 Protein ID WP_011166377.1
Coordinates 794548..795387 (+) Length 280 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7U5HSJ1
Locus tag mmcaprivi_RS03465 Protein ID WP_015545367.1
Coordinates 793952..794548 (+) Length 199 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
mmcaprivi_RS03450 (mmcaprivi_07530) 789076..789570 + 495 WP_011166381.1 membrane protein -
mmcaprivi_RS03455 (mmcaprivi_07540) 789642..792332 + 2691 WP_011166380.1 alanine--tRNA ligase -
mmcaprivi_RS03460 (mmcaprivi_07550) 792438..793742 + 1305 WP_215489652.1 BspA family leucine-rich repeat surface protein -
mmcaprivi_RS03465 (mmcaprivi_07560) 793952..794548 + 597 WP_015545367.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
mmcaprivi_RS03470 (mmcaprivi_07570) 794548..795387 + 840 WP_011166377.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
mmcaprivi_RS03475 795427..796841 - 1415 Protein_696 IS3-like element IS1296 family transposase -
mmcaprivi_RS03480 (mmcaprivi_07630) 796907..798512 - 1606 Protein_697 IS1634-like element IS1634 family transposase -
mmcaprivi_RS03485 (mmcaprivi_07640) 798625..798789 - 165 WP_215489653.1 hypothetical protein -
mmcaprivi_RS05310 (mmcaprivi_07650) 798858..799052 - 195 WP_011166373.1 hypothetical protein -
mmcaprivi_RS05315 (mmcaprivi_07660) 799198..799725 - 528 WP_011166372.1 hypothetical protein -
mmcaprivi_RS05320 (mmcaprivi_07670) 799783..800208 - 426 WP_011166371.1 transglutaminase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-53)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 33073.99 Da        Isoelectric Point: 9.7009

>T38911 WP_011166377.1 NZ_AP024602:794548-795387 [Mycoplasma mycoides]
MNLQKLKSICKRLSSETKTNYNIILKHYFMISILEKIVKSKNKQNFVIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILRTISDVLRYDFTDFIKYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLAIGDVVTPSEIKYNFRNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSFKEFEIDYNILKCACLNTFKKRNTVFNIDLVLSLLNEINQL
DIFELLNNYRQKYFYAQKIEFKILIKSVIKFLEKLKNI

Download         Length: 840 bp

>T38911 NZ_AP024602:794548-795387 [Mycoplasma mycoides]
ATGAACTTACAGAAATTAAAATCAATTTGTAAAAGGTTATCAAGTGAAACAAAAACAAATTATAATATCATCTTAAAACA
TTACTTTATGATATCCATATTAGAAAAAATTGTTAAAAGTAAAAATAAACAAAACTTTGTAATTAAAGGTGGGTTCTTAC
TTTCTAATATGATGAGTTTAAACGAAAGAACCACTCAAGATATAGATTGCTTAATAAAAGGTATCAATTTTGTTAAAGAG
AATATTCTAAGAACTATTTCTGATGTATTAAGATATGATTTTACTGACTTTATAAAATATGAAATAAAAGAAATAACAGA
AATAAAAAAGAGAGACAAATATAATGGATTTAGAGTCAAAATATTATGCAAATTAGAAAAGTTGGAAGAAATAGTAAAAA
TAGATTTAGCAATTGGTGATGTTGTAACACCGTCTGAGATTAAATACAATTTTAGAAATATCTTTTCAAATAGTAGCTTT
GAAATACAAGCATATAATCTAGAAACAATATTAGCTGAAAAAATATTTATAATTAATAATTTAAATATACAATCAACTAG
AATAAAAGATCTTTATGATATTTTTTTAATATATAGCTTTAAAGAGTTTGAGATTGATTATAATATTCTAAAATGTGCTT
GTTTAAATACTTTTAAAAAAAGAAATACTGTTTTTAATATAGATTTAGTACTTAGTTTATTAAATGAAATTAACCAATTA
GATATTTTTGAATTACTTTGAAATAATTACAGGCAAAAATACTTTTACGCCCAAAAAATAGAATTTAAAATACTGATAAA
ATCTGTAATTAAGTTTTTAGAAAAGTTAAAAAATATTTAA

Antitoxin


Download         Length: 199 a.a.        Molecular weight: 23637.30 Da        Isoelectric Point: 9.3217

>AT38911 WP_015545367.1 NZ_AP024602:793952-794548 [Mycoplasma mycoides]
MNYKEQLIKEAKKRAGIITRKEIMNLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKIRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Download         Length: 597 bp

>AT38911 NZ_AP024602:793952-794548 [Mycoplasma mycoides]
ATGAATTATAAAGAACAGCTGATAAAAGAAGCTAAAAAAAGAGCCGGTATTATTACAAGAAAAGAAATTATGAATTTAAA
AATTCCATCAATTTATATTACAAGAATGATTAGAAGTAATGAATTAGAAAAAGTCGATATTGGTATTTATGCTCTAACTT
CTGAAAATTGGTACTATGATCCTGATTATAATTTTAGTATCAGACATAAAACACCTATTTTTTCTTATACTTATGCACTT
ACATTTTTTGATTTTACAGATGTTATTCCAATGTTTCGTGATGTAACTGTTTATCATGGATATAATGCTCATAATTTAGA
CCCACAAACTAGAGTACACTATGTTTCAAAAGATATATATGAACTTGGAGTTGTAGAAGTAAAAACAAATTGTGGTAATA
AAATTAGAGCTTATGATATTGAAAGAACAATTTGTGATTTTATTAAGCATAGAGATAAAATCGAAGCTGAACTATTTGCA
AAAACTATGTATAAATATTCTGAATATGAAAAAAGAGATTGAAAAAAACTTCATGAATATGCTAAAAAAATGAACATTGG
TAAGAAAGTTTATGAAGTTTTTCAAGTATTAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q6MU66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5HSJ1

References