38910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 271933..272584 Replicon chromosome
Accession NZ_AP024601
Organism Polycladomyces abyssicola strain JIR-001

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KI215_RS01400 Protein ID WP_212773849.1
Coordinates 272234..272584 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KI215_RS01395 Protein ID WP_212775006.1
Coordinates 271933..272229 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI215_RS01380 (JIR001_02550) 267961..269547 - 1587 WP_212773846.1 alpha-amylase family glycosyl hydrolase -
KI215_RS01385 (JIR001_02560) 269922..270353 + 432 WP_212773847.1 hypothetical protein -
KI215_RS01390 (JIR001_02570) 270350..271528 + 1179 WP_212773848.1 alanine racemase -
KI215_RS01395 (JIR001_02580) 271933..272229 + 297 WP_212775006.1 ribbon-helix-helix protein, CopG family Antitoxin
KI215_RS01400 (JIR001_02590) 272234..272584 + 351 WP_212773849.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KI215_RS01405 (JIR001_02600) 272771..273784 + 1014 WP_212773850.1 PP2C family protein-serine/threonine phosphatase -
KI215_RS01410 (JIR001_02610) 273841..274167 + 327 WP_212773851.1 STAS domain-containing protein -
KI215_RS01415 (JIR001_02620) 274170..274655 + 486 WP_212773852.1 anti-sigma B factor RsbW -
KI215_RS01420 (JIR001_02630) 274621..275406 + 786 WP_212773853.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-50)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12984.06 Da        Isoelectric Point: 5.1342

>T38910 WP_212773849.1 NZ_AP024601:272234-272584 [Polycladomyces abyssicola]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMNRVNEALMISLGMIDF

Download         Length: 351 bp

>T38910 NZ_AP024601:272234-272584 [Polycladomyces abyssicola]
TTGATTGTCAAGCGTGGCGATGTCTACTTTGCCGATCTATCACCAGTGGTTGGATCGGAACAGGGTGGGGTCAGACCTGT
TCTGGTCATCCAAAACGATATAGGCAACCGGTTTAGCCCCACCGTGATCGTCGCCGCGATTACCGCTCAAATTCAAAAGG
CCAAGTTGCCCACCCATGTGGAGATCGACGCGAAGACCTACGGGTTTGATCGGGACTCGGTGATTTTGTTGGAGCAGATT
CGCACGATTGATAAACAGCGTCTGACCGACAAAATCACCCATTTGGATGAGGAAATGATGAATCGGGTCAACGAAGCGCT
GATGATCAGCTTGGGTATGATCGATTTTTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11407.27 Da        Isoelectric Point: 5.2566

>AT38910 WP_212775006.1 NZ_AP024601:271933-272229 [Polycladomyces abyssicola]
MIGWGCEVLSETKRIMISLPKHLLQEVDGMVAKENSNRSEFIRQAMKLYLQERKKRLIREMMQRGYMEMAKINLNIASEA
FEAEEEADDTLERLVSGV

Download         Length: 297 bp

>AT38910 NZ_AP024601:271933-272229 [Polycladomyces abyssicola]
ATGATTGGTTGGGGGTGCGAAGTTTTGTCCGAAACCAAGCGAATCATGATCAGCCTACCCAAGCATCTGTTGCAAGAAGT
TGACGGTATGGTGGCGAAAGAGAACTCCAATCGAAGCGAATTTATCCGCCAGGCGATGAAGCTGTATCTGCAGGAGAGGA
AAAAACGGTTGATCCGTGAGATGATGCAGCGCGGCTACATGGAGATGGCGAAAATCAATTTGAATATTGCTTCCGAGGCC
TTCGAAGCCGAAGAAGAAGCGGACGACACTTTGGAACGACTGGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References