Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1030992..1031616 Replicon chromosome
Accession NZ_AP024599
Organism Helicobacter pylori strain 3401

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CPY3401_RS04920 Protein ID WP_130779318.1
Coordinates 1030992..1031258 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CPY3401_RS04925 Protein ID WP_221062252.1
Coordinates 1031245..1031616 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPY3401_RS04900 (CPY3401_09950) 1027641..1028408 - 768 WP_096481920.1 ABC transporter ATP-binding protein -
CPY3401_RS04905 (CPY3401_09960) 1028408..1029388 - 981 WP_000921438.1 iron ABC transporter permease -
CPY3401_RS04910 (CPY3401_09970) 1029381..1030223 - 843 WP_221062251.1 SDR family oxidoreductase -
CPY3401_RS04915 (CPY3401_09980) 1030364..1030888 + 525 WP_001120215.1 acyl-CoA thioesterase -
CPY3401_RS04920 (CPY3401_09990) 1030992..1031258 - 267 WP_130779318.1 type II toxin-antitoxin system YafQ family toxin Toxin
CPY3401_RS04925 (CPY3401_10000) 1031245..1031616 - 372 WP_221062252.1 hypothetical protein Antitoxin
CPY3401_RS04930 (CPY3401_10010) 1032084..1034309 - 2226 WP_221062253.1 Hop family adhesin BabA -
CPY3401_RS04945 (CPY3401_10020) 1034668..1035291 + 624 WP_221062254.1 helicase DnaB modulator -
CPY3401_RS04950 (CPY3401_10030) 1035242..1036354 - 1113 WP_221062255.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10451.40 Da        Isoelectric Point: 10.0717

>T38909 WP_130779318.1 NZ_AP024599:c1031258-1030992 [Helicobacter pylori]
MLKIKHHILYKKDFKKLIKNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGNWKPFRECHIKADILLVYLVRDDELILVR
LGSHSELF

Download         Length: 267 bp

>T38909 NZ_AP024599:c1031258-1030992 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTATTAAAAACGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAAGGCAATTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGATGATGAGCTTATTTTAGTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14402.19 Da        Isoelectric Point: 5.0585

>AT38909 WP_221062252.1 NZ_AP024599:c1031616-1031245 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDGKRDCCF
GHETPNLETQQAMREALNGENLETIEDLSAWANEMKKEVNAEN

Download         Length: 372 bp

>AT38909 NZ_AP024599:c1031616-1031245 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTGGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGGTAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACCTTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGCGAGAATTTAGAAACTATTGAAGA
CCTTTCTGCATGGGCAAATGAAATGAAAAAGGAAGTGAATGCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References