Detailed information of TA system TA038908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1517686..1518295
• Replicon: chromosome
• Accession: NZ_AP024597
• Organism: Stygiolobus caldivivus strain KN-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KN1_RS06990
• Protein ID: WP_221290587.1
• Coordinates: 1517686..1518021 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KN1_RS06995
• Protein ID: WP_221286557.1
• Coordinates: 1518071..1518295 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN1_RS06975 (KN1_14400)	1512824..1513180	-	357	WP_221286551.1	DUF1641 domain-containing protein	-
KN1_RS06980 (KN1_14410)	1513144..1516041	-	2898	WP_258712649.1	formate dehydrogenase subunit alpha	-
KN1_RS06985 (KN1_14420)	1516648..1517124	-	477	WP_221286555.1	hypothetical protein	-
KN1_RS06990 (KN1_14430)	1517686..1518021	-	336	WP_221290587.1	PIN domain-containing protein	Toxin
KN1_RS06995 (KN1_14440)	1518071..1518295	-	225	WP_221286557.1	DUF4145 domain-containing protein	Antitoxin
KN1_RS07000 (KN1_14450)	1518762..1518935	+	174	WP_221286560.1	hypothetical protein	-
KN1_RS07005 (KN1_14460)	1519048..1520091	-	1044	WP_221286562.1	transporter	-
KN1_RS07010 (KN1_14470)	1520661..1522424	-	1764	WP_221286564.1	PQQ-binding-like beta-propeller repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (5-98)

Antitoxin

• Putative antitoxin VapB3-like (1-74)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12867.86 Da
• Isoelectric Point: 4.9597

>T38908 WP_221290587.1 NZ_AP024597:c1518021-1517686 [Stygiolobus caldivivus]
IDNVDLDKVYILRLTFYEVGNVIWKESYLHKKVRDPVRTAEVFEEIMKGFRVLEDPPIHSVLKIAVEKGLTYYDASYVYS
SEVNGLTLVSEDKELITKTNAIPLKEFLKEV

Nucleotide

• Length: 336 bp

>T38908 NZ_AP024597:c1518021-1517686 [Stygiolobus caldivivus]
ATAGATAACGTCGATCTAGACAAGGTATACATTTTACGTTTGACGTTTTATGAGGTAGGAAATGTGATATGGAAGGAGTC
TTATCTCCACAAGAAGGTCAGAGATCCCGTACGTACAGCTGAGGTGTTCGAGGAGATAATGAAAGGGTTCAGAGTCTTAG
AAGACCCTCCTATACACAGCGTGTTGAAGATAGCTGTGGAAAAGGGGCTTACCTATTACGATGCCTCATACGTATATTCG
TCAGAAGTAAACGGCTTAACCCTGGTGTCAGAAGACAAGGAGCTTATAACTAAAACGAACGCGATCCCGTTAAAGGAGTT
CCTCAAGGAGGTCTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8879.23 Da
• Isoelectric Point: 5.3582

>AT38908 WP_221286557.1 NZ_AP024597:c1518295-1518071 [Stygiolobus caldivivus]
MSEVLSVRVRRELKRKAEELGINIREIVEKAIEEAIREKEKERIKAMALELKELMRDVSEEDWARAVRESRDER

Nucleotide

• Length: 225 bp

>AT38908 NZ_AP024597:c1518295-1518071 [Stygiolobus caldivivus]
ATGTCAGAGGTCTTGAGCGTGAGGGTGAGGAGGGAGTTAAAGAGGAAGGCAGAAGAGCTCGGGATCAATATTAGGGAGAT
AGTAGAAAAGGCGATTGAAGAAGCTATAAGGGAAAAAGAGAAGGAGCGAATAAAGGCGATGGCGTTAGAGCTTAAGGAGC
TCATGAGGGACGTGAGTGAAGAGGATTGGGCCAGAGCAGTGAGGGAGAGCAGGGACGAGAGGTAA