Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1517686..1518295 Replicon chromosome
Accession NZ_AP024597
Organism Stygiolobus caldivivus strain KN-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KN1_RS06990 Protein ID WP_221290587.1
Coordinates 1517686..1518021 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KN1_RS06995 Protein ID WP_221286557.1
Coordinates 1518071..1518295 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KN1_RS06975 (KN1_14400) 1512824..1513180 - 357 WP_221286551.1 DUF1641 domain-containing protein -
KN1_RS06980 (KN1_14410) 1513144..1516041 - 2898 WP_258712649.1 formate dehydrogenase subunit alpha -
KN1_RS06985 (KN1_14420) 1516648..1517124 - 477 WP_221286555.1 hypothetical protein -
KN1_RS06990 (KN1_14430) 1517686..1518021 - 336 WP_221290587.1 PIN domain-containing protein Toxin
KN1_RS06995 (KN1_14440) 1518071..1518295 - 225 WP_221286557.1 DUF4145 domain-containing protein Antitoxin
KN1_RS07000 (KN1_14450) 1518762..1518935 + 174 WP_221286560.1 hypothetical protein -
KN1_RS07005 (KN1_14460) 1519048..1520091 - 1044 WP_221286562.1 transporter -
KN1_RS07010 (KN1_14470) 1520661..1522424 - 1764 WP_221286564.1 PQQ-binding-like beta-propeller repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-98)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12867.86 Da        Isoelectric Point: 4.9597

>T38908 WP_221290587.1 NZ_AP024597:c1518021-1517686 [Stygiolobus caldivivus]
IDNVDLDKVYILRLTFYEVGNVIWKESYLHKKVRDPVRTAEVFEEIMKGFRVLEDPPIHSVLKIAVEKGLTYYDASYVYS
SEVNGLTLVSEDKELITKTNAIPLKEFLKEV

Download         Length: 336 bp

>T38908 NZ_AP024597:c1518021-1517686 [Stygiolobus caldivivus]
ATAGATAACGTCGATCTAGACAAGGTATACATTTTACGTTTGACGTTTTATGAGGTAGGAAATGTGATATGGAAGGAGTC
TTATCTCCACAAGAAGGTCAGAGATCCCGTACGTACAGCTGAGGTGTTCGAGGAGATAATGAAAGGGTTCAGAGTCTTAG
AAGACCCTCCTATACACAGCGTGTTGAAGATAGCTGTGGAAAAGGGGCTTACCTATTACGATGCCTCATACGTATATTCG
TCAGAAGTAAACGGCTTAACCCTGGTGTCAGAAGACAAGGAGCTTATAACTAAAACGAACGCGATCCCGTTAAAGGAGTT
CCTCAAGGAGGTCTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8879.23 Da        Isoelectric Point: 5.3582

>AT38908 WP_221286557.1 NZ_AP024597:c1518295-1518071 [Stygiolobus caldivivus]
MSEVLSVRVRRELKRKAEELGINIREIVEKAIEEAIREKEKERIKAMALELKELMRDVSEEDWARAVRESRDER

Download         Length: 225 bp

>AT38908 NZ_AP024597:c1518295-1518071 [Stygiolobus caldivivus]
ATGTCAGAGGTCTTGAGCGTGAGGGTGAGGAGGGAGTTAAAGAGGAAGGCAGAAGAGCTCGGGATCAATATTAGGGAGAT
AGTAGAAAAGGCGATTGAAGAAGCTATAAGGGAAAAAGAGAAGGAGCGAATAAAGGCGATGGCGTTAGAGCTTAAGGAGC
TCATGAGGGACGTGAGTGAAGAGGATTGGGCCAGAGCAGTGAGGGAGAGCAGGGACGAGAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References