Detailed information of TA system TA038907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1363131..1363632
• Replicon: chromosome
• Accession: NZ_AP024597
• Organism: Stygiolobus caldivivus strain KN-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KN1_RS14720
• Protein ID: WP_225905804.1
• Coordinates: 1363444..1363632 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KN1_RS06510
• Protein ID: WP_221290245.1
• Coordinates: 1363131..1363364 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN1_RS06485 (KN1_13290)	1358588..1359733	+	1146	WP_221290229.1	mandelate racemase/muconate lactonizing enzyme family protein	-
KN1_RS06490 (KN1_13300)	1359733..1360380	+	648	WP_221290232.1	GntR family transcriptional regulator	-
KN1_RS06495	1360674..1360823	+	150	WP_221290236.1	hypothetical protein	-
KN1_RS06500 (KN1_13310)	1361004..1361588	+	585	WP_221290239.1	IS607 family transposase	-
KN1_RS06505 (KN1_13320)	1361566..1362861	+	1296	WP_221290242.1	RNA-guided endonuclease TnpB family protein	-
KN1_RS06510 (KN1_13330)	1363131..1363364	+	234	WP_221290245.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
KN1_RS14720 (KN1_13340)	1363444..1363632	+	189	WP_225905804.1	hypothetical protein	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (4-45)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6979.05 Da
• Isoelectric Point: 5.5419

>T38907 WP_225905804.1 NZ_AP024597:1363444-1363632 [Stygiolobus caldivivus]
VVPVIVAHELVWFLEGMGLEDRLGDITAYSQHRRAEVVYDCGDHITGAIEVLKKEKTPRFGL

Nucleotide

• Length: 189 bp

>T38907 NZ_AP024597:1363444-1363632 [Stygiolobus caldivivus]
GTGGTCCCAGTAATCGTTGCCCACGAACTGGTCTGGTTTTTAGAAGGCATGGGACTGGAGGACAGGCTCGGCGACATTAC
AGCATACTCACAGCACCGAAGAGCGGAGGTGGTTTACGACTGCGGTGACCACATAACTGGAGCCATAGAGGTCTTAAAGA
AAGAAAAAACTCCCCGTTTCGGATTATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8900.14 Da
• Isoelectric Point: 10.0308

>AT38907 WP_221290245.1 NZ_AP024597:1363131-1363364 [Stygiolobus caldivivus]
MERVKVTRGYQVTIPASIRSKIDIREGDVFEVYLNGDEIVLRKARTQRPRVKLGRELSLEDIEGAIRRGEGESYSRH

Nucleotide

• Length: 234 bp

>AT38907 NZ_AP024597:1363131-1363364 [Stygiolobus caldivivus]
ATGGAGAGGGTAAAGGTAACGAGGGGCTACCAAGTGACTATCCCCGCCTCAATAAGGAGCAAGATCGACATAAGGGAAGG
CGACGTATTTGAGGTCTACTTAAACGGCGACGAGATCGTACTGAGGAAAGCCAGGACGCAGAGGCCCAGAGTAAAGCTCG
GTAGGGAATTATCACTAGAAGATATCGAGGGAGCGATAAGGCGCGGAGAGGGAGAGAGCTATAGTCGACACTAA