Detailed information of TA system TA038906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1244247..1244850
• Replicon: chromosome
• Accession: NZ_AP024597
• Organism: Stygiolobus caldivivus strain KN-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KN1_RS06065
• Protein ID: WP_258712646.1
• Coordinates: 1244518..1244850 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KN1_RS06060
• Protein ID: WP_221290041.1
• Coordinates: 1244247..1244468 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN1_RS06040 (KN1_12390)	1240050..1240439	-	390	WP_221290035.1	PIN domain-containing protein	-
KN1_RS06045 (KN1_12400)	1240436..1240663	-	228	WP_221290036.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
KN1_RS06050 (KN1_12410)	1241094..1242470	+	1377	WP_221290038.1	MFS transporter	-
KN1_RS06055 (KN1_12420)	1242908..1243942	+	1035	WP_221290039.1	hypothetical protein	-
KN1_RS06060 (KN1_12430)	1244247..1244468	+	222	WP_221290041.1	hypothetical protein	Antitoxin
KN1_RS06065 (KN1_12440)	1244518..1244850	+	333	WP_258712646.1	type II toxin-antitoxin system VapC family toxin	Toxin
KN1_RS06070 (KN1_12450)	1245161..1245919	-	759	WP_221290043.1	hypothetical protein	-
KN1_RS06075 (KN1_12460)	1246510..1246662	+	153	WP_221290045.1	heavy metal translocating P-type ATPase metal-binding domain-containing protein	-
KN1_RS06080 (KN1_12470)	1246659..1248008	+	1350	WP_221290061.1	mercury(II) reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (10-101)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12349.60 Da
• Isoelectric Point: 4.9633

>T38906 WP_258712646.1 NZ_AP024597:1244518-1244850 [Stygiolobus caldivivus]
IAEVLKDGETLDLALLEVSNVVWKKVALTKELTEKDAVKLVAVVKDYLPQLLTVDKSLDLMERAMEISIKEKIPVYDSLY
IALAEKKGRLVTGDKKQYEVAIKYVTAELV

Nucleotide

• Length: 333 bp

>T38906 NZ_AP024597:1244518-1244850 [Stygiolobus caldivivus]
ATAGCAGAGGTATTAAAAGATGGAGAGACCTTAGACCTGGCACTCCTCGAGGTCTCAAATGTAGTGTGGAAGAAAGTCGC
GCTTACAAAGGAACTCACTGAAAAGGACGCAGTCAAACTAGTCGCTGTAGTTAAGGACTACCTACCGCAATTATTGACAG
TCGACAAGAGCCTAGACTTAATGGAGAGGGCAATGGAGATCTCTATTAAGGAAAAAATCCCGGTTTACGACTCACTTTAC
ATCGCTTTAGCTGAGAAAAAGGGGAGGCTAGTGACAGGGGATAAGAAACAGTATGAGGTAGCAATAAAGTATGTTACTGC
AGAACTAGTTTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8899.04 Da
• Isoelectric Point: 4.9544

>AT38906 WP_221290041.1 NZ_AP024597:1244247-1244468 [Stygiolobus caldivivus]
MKTVYSFRIDKELREEMERYNIKWNEEIENFIRERVKELKKEEVLKKINETLSTIPETSSSSAEMVRQDRDSN

Nucleotide

• Length: 222 bp

>AT38906 NZ_AP024597:1244247-1244468 [Stygiolobus caldivivus]
ATGAAGACCGTATATAGTTTCAGGATAGACAAGGAATTACGAGAAGAAATGGAGAGGTATAACATTAAGTGGAATGAGGA
GATAGAGAATTTTATAAGAGAAAGGGTTAAAGAGTTGAAAAAGGAAGAGGTGCTGAAGAAAATAAACGAAACCCTCTCCA
CAATTCCAGAGACCTCATCGAGCAGTGCAGAAATGGTGAGGCAGGATAGGGACAGTAATTGA