Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1126640..1127613 Replicon chromosome
Accession NZ_AP024597
Organism Stygiolobus caldivivus strain KN-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KN1_RS05560 Protein ID WP_221289869.1
Coordinates 1126640..1127254 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KN1_RS05565 Protein ID WP_221289870.1
Coordinates 1127260..1127613 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KN1_RS05540 (KN1_11340) 1122524..1123000 + 477 WP_221289865.1 PaREP1 family protein -
KN1_RS05545 (KN1_11350) 1123606..1124347 - 742 Protein_1112 IS1 family transposase -
KN1_RS05550 (KN1_11360) 1124398..1125111 - 714 WP_221289867.1 hypothetical protein -
KN1_RS05555 (KN1_11370) 1125108..1126136 - 1029 WP_221289868.1 nitric oxide response protein -
KN1_RS05560 (KN1_11380) 1126640..1127254 - 615 WP_221289869.1 helix-turn-helix domain-containing protein Toxin
KN1_RS05565 (KN1_11390) 1127260..1127613 - 354 WP_221289870.1 DUF488 family protein Antitoxin
KN1_RS05570 (KN1_11400) 1127834..1128274 - 441 WP_221289871.1 hemerythrin domain-containing protein -
KN1_RS14690 1128386..1128637 - 252 Protein_1118 ferredoxin -
KN1_RS05575 (KN1_11410) 1128817..1130031 + 1215 WP_221289872.1 AAA family ATPase -
KN1_RS05580 (KN1_11420) 1130024..1130326 + 303 WP_221289873.1 hypothetical protein -
KN1_RS05585 (KN1_11430) 1130749..1131084 + 336 WP_221289874.1 hypothetical protein -
KN1_RS05590 (KN1_11450) 1131331..1132563 + 1233 WP_221289877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-107)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23316.55 Da        Isoelectric Point: 9.6554

>T38905 WP_221289869.1 NZ_AP024597:c1127254-1126640 [Stygiolobus caldivivus]
MPKLPFRVTMLIEDHPCEVMKLITVMGLKASVENVKLRESVTDHVLLFESKVKNEDAFKLKSSNVKVLRLTDSKIWVRTN
GCAVCRVLYTSDVVIEKIKVVKEKTLLYTLLVPNTQSLKDFLSKLTNQGIKVTVINTDEISSNELTERQMEILKLAYKLG
YFDDERGITLTELANKLNISPPTLEEILRKALRKVVKYYLDKVG

Download         Length: 615 bp

>T38905 NZ_AP024597:c1127254-1126640 [Stygiolobus caldivivus]
ATGCCCAAGTTACCTTTTAGAGTCACGATGTTGATTGAAGATCACCCTTGCGAGGTAATGAAGCTCATAACCGTAATGGG
GCTTAAGGCGAGTGTAGAGAACGTTAAATTAAGGGAAAGTGTGACCGACCACGTGCTCCTATTCGAGTCGAAGGTCAAGA
ACGAGGACGCGTTTAAGCTCAAGTCATCTAACGTTAAAGTATTAAGGCTGACAGACAGCAAGATATGGGTCAGGACTAAC
GGGTGTGCAGTGTGTAGAGTACTTTATACTTCAGATGTAGTGATAGAGAAGATAAAAGTAGTGAAAGAGAAGACTTTGCT
ATACACCTTGTTAGTCCCTAACACTCAATCGTTAAAGGATTTTCTGTCAAAGCTCACTAACCAAGGGATTAAGGTCACAG
TAATAAACACCGACGAGATAAGCAGTAACGAATTGACTGAGAGGCAGATGGAGATATTAAAATTGGCTTATAAGCTGGGT
TACTTTGACGACGAGAGGGGTATAACTTTAACCGAACTCGCTAATAAGTTGAATATTTCACCACCAACTTTAGAGGAAAT
ATTACGAAAAGCACTGAGAAAAGTAGTCAAATACTACTTGGACAAAGTAGGGTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13916.09 Da        Isoelectric Point: 8.3703

>AT38905 WP_221289870.1 NZ_AP024597:c1127613-1127260 [Stygiolobus caldivivus]
MIKVKRVYDPVEKGDGVRILVDRLWPRGIKKDKVDVWLKDIAPSEELRTWFGHDPDKWEEFKRRYFEELSKNPKLDILLQ
LIKKGEDVTLLYASKSPYNNAVALKEFIDKILNRDDE

Download         Length: 354 bp

>AT38905 NZ_AP024597:c1127613-1127260 [Stygiolobus caldivivus]
ATGATAAAAGTAAAGAGGGTTTACGATCCGGTAGAAAAGGGCGACGGGGTCAGGATATTAGTAGATAGGTTATGGCCGAG
GGGCATTAAAAAGGACAAAGTTGACGTTTGGCTTAAAGACATAGCCCCTAGTGAAGAATTAAGGACGTGGTTCGGCCACG
ACCCCGACAAGTGGGAGGAGTTCAAGAGGAGGTATTTCGAGGAGCTCAGCAAGAACCCCAAGCTAGATATTTTATTGCAG
TTGATCAAGAAGGGTGAGGACGTAACGTTACTTTACGCCTCTAAGTCCCCTTACAATAACGCGGTTGCCCTAAAGGAATT
TATAGATAAAATATTAAACCGAGATGACGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References