Detailed information of TA system TA038903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1806966..1807476
• Replicon: chromosome
• Accession: NZ_AP024595
• Organism: Acinetobacter bouvetii strain JCM 18991

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KI216_RS08570
• Protein ID: WP_018572507.1
• Coordinates: 1807213..1807476 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9DJC4
• Locus tag: KI216_RS08565
• Protein ID: WP_005009713.1
• Coordinates: 1806966..1807229 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI216_RS16135 (ACBO_16540)	1802130..1802300	-	171	WP_228128312.1	hypothetical protein	-
KI216_RS08545 (ACBO_16550)	1802403..1803884	-	1482	WP_005009732.1	PLP-dependent aminotransferase family protein	-
KI216_RS08550 (ACBO_16560)	1803994..1805196	+	1203	WP_005009730.1	benzoate/H(+) symporter BenE family transporter	-
KI216_RS08555 (ACBO_16570)	1805394..1805849	+	456	WP_005009727.1	GNAT family N-acetyltransferase	-
KI216_RS08560 (ACBO_16580)	1806374..1806604	-	231	WP_005009726.1	hypothetical protein	-
KI216_RS08565 (ACBO_16590)	1806966..1807229	+	264	WP_005009713.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KI216_RS08570 (ACBO_16600)	1807213..1807476	+	264	WP_018572507.1	Txe/YoeB family addiction module toxin	Toxin
KI216_RS08575 (ACBO_16610)	1807602..1807847	-	246	WP_026253333.1	hypothetical protein	-
KI216_RS08580 (ACBO_16630)	1808296..1808502	-	207	WP_005009710.1	hypothetical protein	-
KI216_RS08585 (ACBO_16640)	1808681..1810537	+	1857	WP_005009709.1	ABC transporter ATP-binding protein	-
KI216_RS08590 (ACBO_16650)	1810539..1810988	+	450	WP_005009707.1	MaoC family dehydratase	-
KI216_RS08595 (ACBO_16660)	1811163..1812191	+	1029	WP_005009705.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10272.67 Da
• Isoelectric Point: 8.4730

>T38903 WP_018572507.1 NZ_AP024595:1807213-1807476 [Acinetobacter bouvetii]
MKRKTSFTPSAWDDYVYWQSQDKKTLKRINSLIKECQRTPFEGIGKPEALLGDLSGFWSRRIDEQHRLVYAATDAEITII
ACRYHYE

Nucleotide

• Length: 264 bp

>T38903 NZ_AP024595:1807213-1807476 [Acinetobacter bouvetii]
ATGAAACGGAAGACTAGCTTTACCCCTTCAGCTTGGGATGATTATGTATATTGGCAAAGCCAAGACAAAAAAACGCTCAA
GCGAATCAATAGCCTCATAAAGGAATGCCAACGCACACCTTTTGAAGGTATTGGAAAACCTGAAGCTCTACTCGGTGATT
TATCGGGATTTTGGAGCAGAAGGATAGATGAACAGCATAGGCTAGTTTATGCAGCAACAGACGCAGAGATAACGATAATT
GCTTGTCGATATCACTACGAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9726.89 Da
• Isoelectric Point: 4.8087

>AT38903 WP_005009713.1 NZ_AP024595:1806966-1807229 [Acinetobacter bouvetii]
MQVFTYTDARNNLKSVLDKVIDDADVAVITRKEGQHAVVMGQDHYNSVMETLHLISSPKNAAHLANSIAEFRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT38903 NZ_AP024595:1806966-1807229 [Acinetobacter bouvetii]
ATGCAAGTATTTACATATACAGATGCACGTAACAATCTAAAATCCGTTTTAGACAAAGTTATTGATGATGCGGATGTAGC
CGTTATTACTCGCAAAGAAGGTCAACATGCGGTTGTCATGGGTCAAGACCACTACAACAGCGTAATGGAAACATTACATT
TGATATCTTCGCCAAAGAATGCAGCACACCTTGCAAACTCAATTGCAGAGTTTCGTGCATCTAAAGCAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Antitoxin

• AlphaFold DB: N9DJC4