Detailed information of TA system TA038895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4870033..4870609
• Replicon: chromosome
• Accession: NZ_AP024592
• Organism: Klebsiella variicola strain JCM 12419

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: KI238_RS23585
• Protein ID: WP_012542979.1
• Coordinates: 4870322..4870609 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: KI238_RS23580
• Protein ID: WP_012542978.1
• Coordinates: 4870033..4870335 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI238_RS23555 (KLVA_45800)	4865441..4866505	-	1065	WP_008807596.1	DUF2955 domain-containing protein	-
KI238_RS23560 (KLVA_45810)	4866495..4867562	-	1068	WP_063106329.1	HlyD family secretion protein	-
KI238_RS23565 (KLVA_45820)	4867569..4868033	-	465	WP_100698682.1	MarR family transcriptional regulator	-
KI238_RS23570 (KLVA_45830)	4868199..4868363	-	165	WP_008807599.1	DUF1127 domain-containing protein	-
KI238_RS23575 (KLVA_45840)	4868541..4869953	+	1413	WP_012969021.1	PLP-dependent aminotransferase family protein	-
KI238_RS23580 (KLVA_45850)	4870033..4870335	-	303	WP_012542978.1	BrnA antitoxin family protein	Antitoxin
KI238_RS23585 (KLVA_45860)	4870322..4870609	-	288	WP_012542979.1	BrnT family toxin	Toxin
KI238_RS23590 (KLVA_45870)	4870777..4871196	-	420	WP_119867150.1	FosA5 family fosfomycin resistance glutathione transferase	-
KI238_RS23595 (KLVA_45880)	4871190..4872098	-	909	WP_012542980.1	LysR family transcriptional regulator	-
KI238_RS23600 (KLVA_45890)	4872185..4872967	+	783	WP_012542981.1	NAD(P)H-dependent oxidoreductase	-
KI238_RS23605 (KLVA_45900)	4873109..4873693	+	585	WP_022065974.1	TetR/AcrR family transcriptional regulator	-
KI238_RS23610 (KLVA_45910)	4873715..4874518	+	804	WP_022065975.1	winged helix-turn-helix domain-containing protein	-
KI238_RS23615 (KLVA_45920)	4874515..4875033	+	519	WP_004182811.1	FidL-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (38-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11245.77 Da
• Isoelectric Point: 8.6574

>T38895 WP_012542979.1 NZ_AP024592:c4870609-4870322 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T38895 NZ_AP024592:c4870609-4870322 [Klebsiella variicola]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCATTAAGTAATCTACGAAAACATGGAGTCCGGTTTGAAGAAGCGGT
ATTAGTCTTTGACGATCCGCGGCACCTTTCCCGCCAGGAGCGGTTTGAGAATGGTGAATATCGCTGGCAGACCATCGGTC
TTGTGCATGGGATCCTTGTTATCCTGGTGGCGCATTCGGTCCGTTTTGAAAGTGGAACTGAGGTTATTCGTATTATCAGC
GCCCGGAAGGCGGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11379.02 Da
• Isoelectric Point: 10.1284

>AT38895 WP_012542978.1 NZ_AP024592:c4870335-4870033 [Klebsiella variicola]
MSMVKHKRDNTAALTAKRDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Nucleotide

• Length: 303 bp

>AT38895 NZ_AP024592:c4870335-4870033 [Klebsiella variicola]
ATGAGCATGGTTAAACATAAACGCGACAATACGGCGGCGCTTACCGCTAAGCGTGATGCCGAACTCAAAGCGCTAGCGAG
CAAAGCCGATGAGGATATCGATTACAGCGATATCCCCGCTACAGACGATGCGCAATGGTCAGATGCCGTTCGCGGCAAAT
TTTTTCGACCGCTAAAAACACAGGCTTCTGTGCGCATTGATGCCGATGTCATGGAGTGGCTCAAACGTCCAGGAAAAGGC
TATCAAACTCGACTGAATGCGATTTTAAGAGAAGCGATGATTCGCGATCTTAATAAGAAATAG