Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1595371..1596368 | Replicon | chromosome |
| Accession | NZ_AP024592 | ||
| Organism | Klebsiella variicola strain JCM 12419 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | KI238_RS27695 | Protein ID | WP_229531768.1 |
| Coordinates | 1595814..1596368 (-) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A1F2MDT5 |
| Locus tag | KI238_RS07755 | Protein ID | WP_012541033.1 |
| Coordinates | 1595371..1595817 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI238_RS07740 (KLVA_14920) | 1591666..1592664 | + | 999 | WP_008804028.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| KI238_RS07745 (KLVA_14930) | 1592783..1594303 | + | 1521 | WP_008804029.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| KI238_RS07750 (KLVA_14940) | 1594319..1595329 | + | 1011 | WP_002912871.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| KI238_RS07755 (KLVA_14950) | 1595371..1595817 | - | 447 | WP_012541033.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KI238_RS27695 (KLVA_14960) | 1595814..1596368 | - | 555 | WP_229531768.1 | HipA domain-containing protein | Toxin |
| KI238_RS27700 (KLVA_14970) | 1596397..1596918 | - | 522 | WP_025714688.1 | hypothetical protein | - |
| KI238_RS07765 (KLVA_14980) | 1597033..1597764 | - | 732 | WP_008804033.1 | outer membrane permeability protein SanA | - |
| KI238_RS07770 (KLVA_15000) | 1598041..1598925 | - | 885 | WP_012541034.1 | cytidine deaminase | - |
| KI238_RS07775 (KLVA_15010) | 1599054..1599749 | - | 696 | WP_008804035.1 | CidB/LrgB family autolysis modulator | - |
| KI238_RS07780 (KLVA_15020) | 1599739..1600143 | - | 405 | WP_004201620.1 | CidA/LrgA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | galF / cpsACP / wzi / wza / wcaJ / gnd / manC / manB / wbtL / ugd / manC / manB | 1566071..1756450 | 190379 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20710.03 Da Isoelectric Point: 5.7891
>T38883 WP_229531768.1 NZ_AP024592:c1596368-1595814 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL
Download Length: 555 bp
>T38883 NZ_AP024592:c1596368-1595814 [Klebsiella variicola]
ATGAGATTGGGAATGGAGTCAGTCTATTCTCTGTTACAAAAAGCGCCAGCGACGATACTTGATCATGAAACCACGCTGCG
GATCCTGATCGAAAAGATCACATCCAGTAATATGGTAAGAGTACAGAATTATCGCTTTGATGTTCAAGGATTTATCATCG
ATTGGGTACGTCGAGACTTATTAAACATTATTTTTGGCAATAGTGATAACCATGGACGTAATACTGCATTTATGAAAGCA
GATAATGAAATTATCCTTGCGCCAATCTACGATTTTGCACCAATGAAAGCCGACCCGGAAGGTATACCGCGCACGATGAA
GTGGTCATTAGCCTGCGAATCAGGAGGCGAATATAACTTTGGCGCCATCGCACAAGCTTTGGCTGAATGGATCACCCCTG
ACACATTGCTTAATGCTTTAAGTGAAACCGCATCTCAACTCGTTGATTTACCATCCCGTCTTAAAGTACGCGGCGTTCCT
GTTCAGATTCTGGAAATGCCATCAATTGGTTTTAAATTTATACCTGACAAACTCGCTCGCTGGGGGCTGTTATGA
ATGAGATTGGGAATGGAGTCAGTCTATTCTCTGTTACAAAAAGCGCCAGCGACGATACTTGATCATGAAACCACGCTGCG
GATCCTGATCGAAAAGATCACATCCAGTAATATGGTAAGAGTACAGAATTATCGCTTTGATGTTCAAGGATTTATCATCG
ATTGGGTACGTCGAGACTTATTAAACATTATTTTTGGCAATAGTGATAACCATGGACGTAATACTGCATTTATGAAAGCA
GATAATGAAATTATCCTTGCGCCAATCTACGATTTTGCACCAATGAAAGCCGACCCGGAAGGTATACCGCGCACGATGAA
GTGGTCATTAGCCTGCGAATCAGGAGGCGAATATAACTTTGGCGCCATCGCACAAGCTTTGGCTGAATGGATCACCCCTG
ACACATTGCTTAATGCTTTAAGTGAAACCGCATCTCAACTCGTTGATTTACCATCCCGTCTTAAAGTACGCGGCGTTCCT
GTTCAGATTCTGGAAATGCCATCAATTGGTTTTAAATTTATACCTGACAAACTCGCTCGCTGGGGGCTGTTATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16396.05 Da Isoelectric Point: 10.5417
>AT38883 WP_012541033.1 NZ_AP024592:c1595817-1595371 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK
Download Length: 447 bp
>AT38883 NZ_AP024592:c1595817-1595371 [Klebsiella variicola]
ATGAAGACCCTGAATAAAAAAGAAACAGAAATCCAAAATACCTTAGCCAGGCTGCGGGCGGATAACCCACCATCCCTACC
CGCCACCGGGGTAACGGCTACAGAAAAAAAAGCTCGTTCAGAGATAAGCAGACAACGCGTCTCGGCTGGTTTAAAAAAAG
TCAAAACGGTCGATCGTCAGGCGGTCATTCACGCCATTATCCATGACATCATGCTAGGCGCCATCAGCCAGGGAGAGGCC
CTGAAAAAACTGAGAGTAGAAGTTCTGGGTTTACGCCAGGATGAATATGCCCGGCTAGTGGATGTCTCTCGTAAGACCTT
ATCTGATGTGGAAAATGATAAAGGCAATTATTCTGCCGAGATCATTAATAAAATCTATAAGCCGTTTGGCCTTGAAACAG
GACTCGTCCCTATTTCTAAAACACTTATTTCTTCTCTATTTAAATAG
ATGAAGACCCTGAATAAAAAAGAAACAGAAATCCAAAATACCTTAGCCAGGCTGCGGGCGGATAACCCACCATCCCTACC
CGCCACCGGGGTAACGGCTACAGAAAAAAAAGCTCGTTCAGAGATAAGCAGACAACGCGTCTCGGCTGGTTTAAAAAAAG
TCAAAACGGTCGATCGTCAGGCGGTCATTCACGCCATTATCCATGACATCATGCTAGGCGCCATCAGCCAGGGAGAGGCC
CTGAAAAAACTGAGAGTAGAAGTTCTGGGTTTACGCCAGGATGAATATGCCCGGCTAGTGGATGTCTCTCGTAAGACCTT
ATCTGATGTGGAAAATGATAAAGGCAATTATTCTGCCGAGATCATTAATAAAATCTATAAGCCGTTTGGCCTTGAAACAG
GACTCGTCCCTATTTCTAAAACACTTATTTCTTCTCTATTTAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|