Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789896..790553 Replicon chromosome
Accession NZ_AP024592
Organism Klebsiella variicola strain JCM 12419

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KI238_RS03895 Protein ID WP_002916310.1
Coordinates 790143..790553 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KI238_RS03890 Protein ID WP_002916312.1
Coordinates 789896..790162 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI238_RS03865 (KLVA_07440) 785046..786479 - 1434 WP_119866734.1 6-phospho-beta-glucosidase BglA -
KI238_RS03870 (KLVA_07450) 786599..787327 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
KI238_RS03875 (KLVA_07460) 787378..787689 + 312 WP_109848735.1 N(4)-acetylcytidine aminohydrolase -
KI238_RS03880 (KLVA_07470) 787852..788511 + 660 WP_008806429.1 hemolysin III family protein -
KI238_RS03885 (KLVA_07480) 788667..789650 - 984 WP_119866735.1 tRNA-modifying protein YgfZ -
KI238_RS03890 (KLVA_07490) 789896..790162 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KI238_RS03895 (KLVA_07500) 790143..790553 + 411 WP_002916310.1 protein YgfX Toxin
KI238_RS03900 (KLVA_07510) 790560..791081 - 522 WP_008806427.1 flavodoxin FldB -
KI238_RS03905 (KLVA_07520) 791182..792078 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
KI238_RS03910 (KLVA_07530) 792101..792814 + 714 WP_064166672.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KI238_RS03915 (KLVA_07540) 792820..794553 + 1734 WP_049139238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T38882 WP_002916310.1 NZ_AP024592:790143-790553 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T38882 NZ_AP024592:790143-790553 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT38882 WP_002916312.1 NZ_AP024592:789896-790162 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT38882 NZ_AP024592:789896-790162 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References