38880

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1654823..1655352 Replicon chromosome
Accession NZ_AP024589
Organism Staphylococcus auricularis strain JCM 2421

Toxin (Protein)


Gene name mazF Uniprot ID A0A2K4C3I5
Locus tag KI212_RS07955 Protein ID WP_059107861.1
Coordinates 1654823..1655185 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K4C4W9
Locus tag KI212_RS07960 Protein ID WP_059107862.1
Coordinates 1655182..1655352 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI212_RS07935 (JCM2421_15810) 1651733..1652503 - 771 WP_059107857.1 RNA polymerase sigma factor SigB -
KI212_RS07940 (JCM2421_15820) 1652478..1652957 - 480 WP_059107858.1 anti-sigma B factor RsbW -
KI212_RS07945 (JCM2421_15830) 1652959..1653285 - 327 WP_059107859.1 anti-sigma factor antagonist -
KI212_RS07950 (JCM2421_15840) 1653362..1654363 - 1002 WP_059107860.1 PP2C family protein-serine/threonine phosphatase -
KI212_RS07955 (JCM2421_15850) 1654823..1655185 - 363 WP_059107861.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KI212_RS07960 (JCM2421_15860) 1655182..1655352 - 171 WP_059107862.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KI212_RS07965 (JCM2421_15870) 1655443..1656591 - 1149 WP_059107863.1 alanine racemase -
KI212_RS07970 (JCM2421_15880) 1656941..1657300 - 360 WP_059107864.1 holo-ACP synthase -
KI212_RS07975 (JCM2421_15890) 1657358..1658110 - 753 WP_059107865.1 PH domain-containing protein -
KI212_RS07980 (JCM2421_15900) 1658103..1659611 - 1509 WP_059107866.1 PH domain-containing protein -
KI212_RS07985 (JCM2421_15910) 1659604..1660083 - 480 WP_059107867.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13664.98 Da        Isoelectric Point: 10.2885

>T38880 WP_059107861.1 NZ_AP024589:c1655185-1654823 [Staphylococcus auricularis]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMEEVNRAIFISLGLHNMKHFKS

Download         Length: 363 bp

>T38880 NZ_AP024589:c1655185-1654823 [Staphylococcus auricularis]
ATGATGAGACGAGGAGATGTATATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGGCCTGTTGT
TATCATTCAAAATGATACTGGGAATAAATATAGTCCTACCGTAATTGTCGCTGCAATTACAGGTAGGATTAATAAAGCTA
AAATTCCAACCCATGTAGAAATAGACAAGAAGAAATATAAATTAGATAAAGATTCAGTTATCTTGTTAGAACAAATTCGA
ACATTAGATAAAAAGAGGCTGAAAGAGAAATTAACATATCTATCTGACGAGAAGATGGAAGAAGTAAATCGTGCTATCTT
CATAAGTTTAGGGTTACATAATATGAAACATTTCAAATCATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6441.01 Da        Isoelectric Point: 4.0115

>AT38880 WP_059107862.1 NZ_AP024589:c1655352-1655182 [Staphylococcus auricularis]
MSNFNTTRYHNMEQILKEGYSQMADLNLSLATEAFPFECEACDCNESFLSSNHNNE

Download         Length: 171 bp

>AT38880 NZ_AP024589:c1655352-1655182 [Staphylococcus auricularis]
ATGTCTAATTTTAACACTACGAGATATCACAATATGGAGCAAATCTTAAAAGAAGGCTATTCACAAATGGCCGATCTTAA
TCTCTCCCTAGCAACAGAAGCTTTTCCTTTCGAATGTGAAGCTTGTGATTGTAACGAATCATTCCTCAGCTCCAATCACA
ATAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4C3I5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4C4W9

References