Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 58356..58999 | Replicon | plasmid pCIAM-2 |
| Accession | NZ_AP024587 | ||
| Organism | Citrobacter amalonaticus strain JCM 1661 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | KI228_RS23560 | Protein ID | WP_121572286.1 |
| Coordinates | 58356..58772 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | - |
| Locus tag | KI228_RS23565 | Protein ID | WP_121572285.1 |
| Coordinates | 58769..58999 (-) | Length | 77 a.a. |
Genomic Context
Location: 53665..54423 (759 bp)
Type: Others
Protein ID: WP_047732337.1
Type: Others
Protein ID: WP_047732337.1
Location: 54457..55638 (1182 bp)
Type: Others
Protein ID: WP_141227223.1
Type: Others
Protein ID: WP_141227223.1
Location: 55720..56349 (630 bp)
Type: Others
Protein ID: WP_063136851.1
Type: Others
Protein ID: WP_063136851.1
Location: 57140..58210 (1071 bp)
Type: Others
Protein ID: WP_141227224.1
Type: Others
Protein ID: WP_141227224.1
Location: 59273..60298 (1026 bp)
Type: Others
Protein ID: WP_121572284.1
Type: Others
Protein ID: WP_121572284.1
Location: 61894..62256 (363 bp)
Type: Others
Protein ID: WP_039265233.1
Type: Others
Protein ID: WP_039265233.1
Location: 62319..62885 (567 bp)
Type: Others
Protein ID: WP_141227225.1
Type: Others
Protein ID: WP_141227225.1
Location: 62882..63661 (780 bp)
Type: Others
Protein ID: WP_141227226.1
Type: Others
Protein ID: WP_141227226.1
Location: 58356..58772 (417 bp)
Type: Toxin
Protein ID: WP_121572286.1
Type: Toxin
Protein ID: WP_121572286.1
Location: 58769..58999 (231 bp)
Type: Antitoxin
Protein ID: WP_121572285.1
Type: Antitoxin
Protein ID: WP_121572285.1
Location: 60346..61284 (939 bp)
Type: Others
Protein ID: WP_121572283.1
Type: Others
Protein ID: WP_121572283.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI228_RS23540 (CIAM_46000) | 53665..54423 | + | 759 | WP_047732337.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| KI228_RS23545 (CIAM_46010) | 54457..55638 | + | 1182 | WP_141227223.1 | MFS transporter | - |
| KI228_RS23550 (CIAM_46020) | 55720..56349 | + | 630 | WP_063136851.1 | DUF1349 domain-containing protein | - |
| KI228_RS23555 | 57140..58210 | + | 1071 | WP_141227224.1 | hypothetical protein | - |
| KI228_RS23560 (CIAM_46040) | 58356..58772 | - | 417 | WP_121572286.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KI228_RS23565 (CIAM_46050) | 58769..58999 | - | 231 | WP_121572285.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KI228_RS23570 (CIAM_46060) | 59273..60298 | + | 1026 | WP_121572284.1 | hypothetical protein | - |
| KI228_RS23575 (CIAM_46070) | 60346..61284 | - | 939 | WP_121572283.1 | hypothetical protein | - |
| KI228_RS23580 (CIAM_46080) | 61894..62256 | + | 363 | WP_039265233.1 | hypothetical protein | - |
| KI228_RS23585 (CIAM_46090) | 62319..62885 | + | 567 | WP_141227225.1 | hypothetical protein | - |
| KI228_RS23590 (CIAM_46100) | 62882..63661 | + | 780 | WP_141227226.1 | site-specific integrase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..125776 | 125776 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15133.65 Da Isoelectric Point: 6.2225
>T38879 WP_121572286.1 NZ_AP024587:c58772-58356 [Citrobacter amalonaticus]
VNKTYMLDTCICSFIMREQPEAVLKHLEQAVLRNQRIVIPVITYAEMRFGATGPKVSPRHIELVDAFCARLDAILPWDSA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGVVLVTNNVREFERVPGLVLEDWVK
VNKTYMLDTCICSFIMREQPEAVLKHLEQAVLRNQRIVIPVITYAEMRFGATGPKVSPRHIELVDAFCARLDAILPWDSA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGVVLVTNNVREFERVPGLVLEDWVK
Download Length: 417 bp
>T38879 NZ_AP024587:c58772-58356 [Citrobacter amalonaticus]
GTGAACAAAACCTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCATCT
GGAGCAGGCGGTGCTGCGCAACCAGCGCATCGTTATCCCGGTCATCACCTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGTCTCGCCGCGCCACATTGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACAGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTCGCGCTGCGGCTCGCCGGAACCCCGATAGGCCCGAACGACACGGCGATCGC
CGGGCACGCCATTGCGGCCGGCGTCGTGCTGGTGACGAATAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGGTACTGG
AAGACTGGGTTAAATAG
GTGAACAAAACCTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCATCT
GGAGCAGGCGGTGCTGCGCAACCAGCGCATCGTTATCCCGGTCATCACCTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGTCTCGCCGCGCCACATTGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACAGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTCGCGCTGCGGCTCGCCGGAACCCCGATAGGCCCGAACGACACGGCGATCGC
CGGGCACGCCATTGCGGCCGGCGTCGTGCTGGTGACGAATAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGGTACTGG
AAGACTGGGTTAAATAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8779.86 Da Isoelectric Point: 4.1211
>AT38879 WP_121572285.1 NZ_AP024587:c58999-58769 [Citrobacter amalonaticus]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVPPTWDSFLELEKADPDFMAEREDVVTDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVPPTWDSFLELEKADPDFMAEREDVVTDEGRFDL
Download Length: 231 bp
>AT38879 NZ_AP024587:c58999-58769 [Citrobacter amalonaticus]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCCGCCGACCTGGGATTCATTCCTGGAGCTCG
AAAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTGACCTGTGA
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCCGCCGACCTGGGATTCATTCCTGGAGCTCG
AAAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTGACCTGTGA