Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 58356..58999 Replicon plasmid pCIAM-2
Accession NZ_AP024587
Organism Citrobacter amalonaticus strain JCM 1661

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag KI228_RS23560 Protein ID WP_121572286.1
Coordinates 58356..58772 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag KI228_RS23565 Protein ID WP_121572285.1
Coordinates 58769..58999 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI228_RS23540 (CIAM_46000) 53665..54423 + 759 WP_047732337.1 DeoR/GlpR family DNA-binding transcription regulator -
KI228_RS23545 (CIAM_46010) 54457..55638 + 1182 WP_141227223.1 MFS transporter -
KI228_RS23550 (CIAM_46020) 55720..56349 + 630 WP_063136851.1 DUF1349 domain-containing protein -
KI228_RS23555 57140..58210 + 1071 WP_141227224.1 hypothetical protein -
KI228_RS23560 (CIAM_46040) 58356..58772 - 417 WP_121572286.1 type II toxin-antitoxin system VapC family toxin Toxin
KI228_RS23565 (CIAM_46050) 58769..58999 - 231 WP_121572285.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KI228_RS23570 (CIAM_46060) 59273..60298 + 1026 WP_121572284.1 hypothetical protein -
KI228_RS23575 (CIAM_46070) 60346..61284 - 939 WP_121572283.1 hypothetical protein -
KI228_RS23580 (CIAM_46080) 61894..62256 + 363 WP_039265233.1 hypothetical protein -
KI228_RS23585 (CIAM_46090) 62319..62885 + 567 WP_141227225.1 hypothetical protein -
KI228_RS23590 (CIAM_46100) 62882..63661 + 780 WP_141227226.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125776 125776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15133.65 Da        Isoelectric Point: 6.2225

>T38879 WP_121572286.1 NZ_AP024587:c58772-58356 [Citrobacter amalonaticus]
VNKTYMLDTCICSFIMREQPEAVLKHLEQAVLRNQRIVIPVITYAEMRFGATGPKVSPRHIELVDAFCARLDAILPWDSA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGVVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

>T38879 NZ_AP024587:c58772-58356 [Citrobacter amalonaticus]
GTGAACAAAACCTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCATCT
GGAGCAGGCGGTGCTGCGCAACCAGCGCATCGTTATCCCGGTCATCACCTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGTCTCGCCGCGCCACATTGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACAGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTCGCGCTGCGGCTCGCCGGAACCCCGATAGGCCCGAACGACACGGCGATCGC
CGGGCACGCCATTGCGGCCGGCGTCGTGCTGGTGACGAATAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGGTACTGG
AAGACTGGGTTAAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.86 Da        Isoelectric Point: 4.1211

>AT38879 WP_121572285.1 NZ_AP024587:c58999-58769 [Citrobacter amalonaticus]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVPPTWDSFLELEKADPDFMAEREDVVTDEGRFDL

Download         Length: 231 bp

>AT38879 NZ_AP024587:c58999-58769 [Citrobacter amalonaticus]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCCGCCGACCTGGGATTCATTCCTGGAGCTCG
AAAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References