38875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3992413..3993082 Replicon chromosome
Accession NZ_AP024585
Organism Citrobacter amalonaticus strain JCM 1661

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KI228_RS18900 Protein ID WP_141227650.1
Coordinates 3992413..3992745 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KI228_RS18905 Protein ID WP_097485886.1
Coordinates 3992765..3993082 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI228_RS18875 (CIAM_36990) 3988103..3989125 + 1023 WP_000155278.1 autoinducer 2 ABC transporter substrate-binding protein LsrB -
KI228_RS18880 (CIAM_37000) 3989154..3990029 + 876 WP_000774153.1 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase -
KI228_RS18885 (CIAM_37010) 3990078..3990368 + 291 WP_044264508.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase -
KI228_RS18890 (CIAM_37020) 3990379..3991125 + 747 WP_061069582.1 epimerase -
KI228_RS18895 (CIAM_37030) 3991661..3992146 - 486 WP_097485888.1 GNAT family N-acetyltransferase -
KI228_RS18900 (CIAM_37040) 3992413..3992745 - 333 WP_141227650.1 TA system toxin CbtA family protein Toxin
KI228_RS18905 (CIAM_37050) 3992765..3993082 - 318 WP_097485886.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KI228_RS18910 (CIAM_37060) 3993101..3993322 - 222 WP_097485885.1 DUF987 domain-containing protein -
KI228_RS18915 (CIAM_37070) 3993331..3993813 - 483 WP_141227651.1 DNA repair protein RadC -
KI228_RS18920 (CIAM_37080) 3993822..3994280 - 459 WP_097485883.1 antirestriction protein -
KI228_RS18925 (CIAM_37090) 3994366..3994602 - 237 WP_025760300.1 DUF905 domain-containing protein -
KI228_RS18930 (CIAM_37100) 3994680..3995090 - 411 WP_039556163.1 hypothetical protein -
KI228_RS18935 (CIAM_37110) 3995157..3995594 - 438 WP_141227652.1 hypothetical protein -
KI228_RS18940 (CIAM_37120) 3995636..3996172 - 537 WP_032686431.1 DUF4339 domain-containing protein -
KI228_RS18945 (CIAM_37130) 3996198..3996908 - 711 WP_025760296.1 DeoR family transcriptional regulator -
KI228_RS18950 (CIAM_37140) 3997117..3997941 - 825 WP_097485882.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3992413..4013366 20953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-100)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12476.48 Da        Isoelectric Point: 6.7016

>T38875 WP_141227650.1 NZ_AP024585:c3992745-3992413 [Citrobacter amalonaticus]
MKTLPATISRATKPCLSPVAVWQMLLTRLLDQHYGLTLNDTPFSDETVIKGHIDAGITLADAVNFLVEKYELVRIDRKGF
SCHEQSPYLRGIDILRAKRELDYCNEIVIT

Download         Length: 333 bp

>T38875 NZ_AP024585:c3992745-3992413 [Citrobacter amalonaticus]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGACGAAGCCCTGTCTGTCGCCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGCCTGTTGGATCAACACTATGGCCTGACGCTAAACGACACGCCATTCAGTGATGAAACTGTTATTAAGGGACATATCG
ATGCTGGTATCACTCTGGCCGATGCGGTCAATTTTCTGGTGGAAAAGTACGAACTGGTTCGCATCGATCGTAAGGGGTTT
AGTTGTCATGAACAATCACCATACCTTCGGGGTATCGATATACTCCGAGCGAAAAGAGAACTGGATTATTGTAATGAAAT
CGTAATAACCTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11939.48 Da        Isoelectric Point: 6.6998

>AT38875 WP_097485886.1 NZ_AP024585:c3993082-3992765 [Citrobacter amalonaticus]
MSNITWGLQRDTTPRLGARLVQEGNRLYYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTGELNPRHAHRVTLYL
DGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT38875 NZ_AP024585:c3993082-3992765 [Citrobacter amalonaticus]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGCAACCGGCT
GTACTATCTGGCTGACCGGGCCAGTATTACTGGTAAATTCAGTGACGCTGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAACTGAATCCTCGTCATGCCCACAGAGTCACCCTGTACCTC
GACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCTGTTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References