Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3876875..3877529 Replicon chromosome
Accession NZ_AP024585
Organism Citrobacter amalonaticus strain JCM 1661

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag KI228_RS18320 Protein ID WP_044254016.1
Coordinates 3876875..3877282 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag KI228_RS18325 Protein ID WP_042322123.1
Coordinates 3877263..3877529 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI228_RS18300 (CIAM_35870) 3872780..3874513 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
KI228_RS18305 (CIAM_35880) 3874519..3875232 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KI228_RS18310 (CIAM_35890) 3875256..3876152 - 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
KI228_RS18315 (CIAM_35900) 3876253..3876774 + 522 WP_042999366.1 flavodoxin FldB -
KI228_RS18320 (CIAM_35910) 3876875..3877282 - 408 WP_044254016.1 protein YgfX Toxin
KI228_RS18325 (CIAM_35920) 3877263..3877529 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
KI228_RS18330 (CIAM_35930) 3877786..3878766 + 981 WP_061069610.1 tRNA-modifying protein YgfZ -
KI228_RS18335 (CIAM_35940) 3878847..3879506 - 660 WP_044264418.1 hemolysin III family protein -
KI228_RS18340 (CIAM_35950) 3879669..3879980 - 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
KI228_RS18345 (CIAM_35960) 3880033..3880761 + 729 WP_044264419.1 MurR/RpiR family transcriptional regulator -
KI228_RS18350 (CIAM_35970) 3880881..3882314 + 1434 WP_141227643.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T38874 WP_044254016.1 NZ_AP024585:c3877282-3876875 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T38874 NZ_AP024585:c3877282-3876875 [Citrobacter amalonaticus]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTCCTTCTGCATGGGCTGGTGGCCGC
GGCGATTCTATTAATGCCATGGCCGCTGAGCTACACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTGTTTGACTGTG
TCCGCAGCCAGCGGCGAATTAACGCCCGTCAGGGAGAGGTCAAACTTCTGATGGATGGACGACTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAAAACCGGCATGATGCTGCGCTTGCGCTCTGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATAAGGCGGAATGGCGGGATTTACGCCGCCTGATGATGCAACCGTCGACGC
AAGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT38874 WP_042322123.1 NZ_AP024585:c3877529-3877263 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT38874 NZ_AP024585:c3877529-3877263 [Citrobacter amalonaticus]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAACGTATTTTTATCCGCCTGCTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References