Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1294555..1295175 Replicon chromosome
Accession NZ_AP024585
Organism Citrobacter amalonaticus strain JCM 1661

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KI228_RS06120 Protein ID WP_001280991.1
Coordinates 1294555..1294773 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q8DH98
Locus tag KI228_RS06125 Protein ID WP_042324455.1
Coordinates 1294801..1295175 (-) Length 125 a.a.

Genomic Context

KI228_RS06090KI228_RS06095KI228_RS06105KI228_RS06100KI228_RS06110KI228_RS06115KI228_RS06120KI228_RS06125KI228_RS06130KI228_RS06135
Location: 1290208..1290804 (597 bp)
Type: Others
Protein ID: WP_061070461.1
Location: 1290887..1291240 (354 bp)
Type: Others
Protein ID: WP_043001561.1
Location: 1293053..1293193 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1291280..1292830 (1551 bp)
Type: Others
Protein ID: WP_054176085.1
Location: 1293243..1293713 (471 bp)
Type: Others
Protein ID: WP_061070460.1
Location: 1293827..1294378 (552 bp)
Type: Others
Protein ID: WP_044258934.1
Location: 1294555..1294773 (219 bp)
Type: Toxin
Protein ID: WP_001280991.1
Location: 1294801..1295175 (375 bp)
Type: Antitoxin
Protein ID: WP_042324455.1
Location: 1295687..1298836 (3150 bp)
Type: Others
Protein ID: WP_043001557.1
Location: 1298859..1300052 (1194 bp)
Type: Others
Protein ID: WP_043001556.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KI228_RS06090 (CIAM_11910)1290208..1290804+597WP_061070461.1membrane protein-
KI228_RS06095 (CIAM_11920)1290887..1291240+354WP_043001561.1DUF1428 family protein-
KI228_RS06100 (CIAM_11930)1291280..1292830-1551WP_054176085.1EAL domain-containing protein-
KI228_RS061051293053..1293193+141WP_003859006.1type B 50S ribosomal protein L36-
KI228_RS06110 (CIAM_11940)1293243..1293713-471WP_061070460.1YlaC family protein-
KI228_RS06115 (CIAM_11950)1293827..1294378-552WP_044258934.1maltose O-acetyltransferase-
KI228_RS06120 (CIAM_11960)1294555..1294773-219WP_001280991.1HHA domain-containing proteinToxin
KI228_RS06125 (CIAM_11970)1294801..1295175-375WP_042324455.1Hha toxicity modulator TomBAntitoxin
KI228_RS06130 (CIAM_11980)1295687..1298836-3150WP_043001557.1efflux RND transporter permease AcrB-
KI228_RS06135 (CIAM_11990)1298859..1300052-1194WP_043001556.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T38865 WP_001280991.1 NZ_AP024585:c1294773-1294555 [Citrobacter amalonaticus]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T38865 NZ_AP024585:c1294773-1294555 [Citrobacter amalonaticus]
ATGTCCGATAAACCATTAACTAAAACTGATTATTTGATGCGCTTGCGACGCTGTCAGACAATTGACACACTTGAACGCGT
GATTGAGAAAAATAAATATGAATTATCTGACAATGAATTGGCTGTATTTTACTCAGCCGCCGATCACCGTCTTGCAGAAT
TGACGATGAATAAACTTTACGACAAGATCCCCTCCTCCGTCTGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8989

>AT38865 WP_042324455.1 NZ_AP024585:c1295175-1294801 [Citrobacter amalonaticus]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT38865 NZ_AP024585:c1295175-1294801 [Citrobacter amalonaticus]
ATGGATGAATACTCACCCAAAAGACATGATATAGCGCAGCTTAAATTTCTTTGTGAAACGCTTTATCACGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTTCAACTCAACGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAGGACAATAAGCTGATTGAGCAGATTGATGAATATCTG
GACGACACATTTATGTTGTTCAGCAGTTATGGCATTAATGCGCAGGATCTGCAGAAATGGCGGAAATCAGGTAATCGCTT
GTTCCGTTGCTTTGTGAATGCCACCAGAGCTAACCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4ICG

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3Q8DH98

References