Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795540..796197 Replicon chromosome
Accession NZ_AP024572
Organism Klebsiella pneumoniae strain KpWEA3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L6447_RS03955 Protein ID WP_002916310.1
Coordinates 795787..796197 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L6447_RS03950 Protein ID WP_002916312.1
Coordinates 795540..795806 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6447_RS03925 (MAKP5_07590) 790696..792129 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L6447_RS03930 (MAKP5_07600) 792248..792976 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L6447_RS03935 (MAKP5_07610) 793026..793337 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L6447_RS03940 (MAKP5_07620) 793501..794160 + 660 WP_002916317.1 hemolysin III family protein -
L6447_RS03945 (MAKP5_07630) 794311..795294 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L6447_RS03950 (MAKP5_07640) 795540..795806 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L6447_RS03955 (MAKP5_07650) 795787..796197 + 411 WP_002916310.1 protein YgfX Toxin
L6447_RS03960 (MAKP5_07660) 796204..796725 - 522 WP_004144730.1 flavodoxin FldB -
L6447_RS03965 (MAKP5_07670) 796826..797722 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L6447_RS03970 (MAKP5_07680) 797745..798458 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L6447_RS03975 (MAKP5_07690) 798464..800197 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T38807 WP_002916310.1 NZ_AP024572:795787-796197 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T38807 NZ_AP024572:795787-796197 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT38807 WP_002916312.1 NZ_AP024572:795540-795806 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT38807 NZ_AP024572:795540-795806 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References