Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4703317..4703765 Replicon chromosome
Accession NZ_AP024565
Organism Microcystis aeruginosa strain NIES-88

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LC603172_RS23550 Protein ID WP_204377826.1
Coordinates 4703559..4703765 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LC603172_RS23545 Protein ID WP_061431729.1
Coordinates 4703317..4703559 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC603172_RS23515 4698759..4698905 - 147 WP_192845998.1 hypothetical protein -
LC603172_RS23520 (MAN88_45740) 4699148..4699450 - 303 WP_002761852.1 DUF3181 family protein -
LC603172_RS23525 (MAN88_45750) 4699443..4699697 - 255 WP_002761850.1 hypothetical protein -
LC603172_RS23530 (MAN88_45760) 4699806..4701674 - 1869 WP_061431523.1 sodium:proton antiporter -
LC603172_RS23535 (MAN88_45770) 4701832..4702770 - 939 WP_239698064.1 PEP-CTERM sorting domain-containing protein -
LC603172_RS23540 (MAN88_45780) 4702991..4703206 + 216 WP_002801839.1 hypothetical protein -
LC603172_RS23545 (MAN88_45790) 4703317..4703559 + 243 WP_061431729.1 DUF2281 domain-containing protein Antitoxin
LC603172_RS23550 (MAN88_45800) 4703559..4703765 + 207 WP_204377826.1 hypothetical protein Toxin
LC603172_RS23555 (MAN88_45810) 4703747..4705843 - 2097 WP_061431520.1 phosphate acetyltransferase -
LC603172_RS23560 (MAN88_45820) 4706053..4706319 - 267 WP_155726640.1 hypothetical protein -
LC603172_RS23565 (MAN88_45830) 4706283..4708079 - 1797 WP_061431519.1 N-acetylmuramoyl-L-alanine amidase -
LC603172_RS23570 4708172..4708336 + 165 WP_155726639.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Domain of unknown function DUF2281

(7-79)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7831.05 Da        Isoelectric Point: 4.3806

>T38764 WP_204377826.1 NZ_AP024565:4703559-4703765 [Microcystis aeruginosa]
MRSALIDTHVFIWLAEDYPILPVSLRDSLENTDNVFVSIASFWEISIKVKIGKLSLCSEMTITQKDWD

Download         Length: 207 bp

>T38764 NZ_AP024565:4703559-4703765 [Microcystis aeruginosa]
ATGAGGAGTGCTTTAATAGATACTCATGTCTTTATCTGGTTAGCTGAGGATTACCCGATTTTGCCTGTTTCGCTGCGAGA
TAGTCTTGAAAATACCGATAATGTTTTTGTAAGTATTGCTAGTTTTTGGGAAATATCGATCAAGGTAAAAATTGGTAAAC
TCTCTCTCTGTTCTGAAATGACGATAACTCAAAAAGATTGGGATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9140.33 Da        Isoelectric Point: 4.8047

>AT38764 WP_061431729.1 NZ_AP024565:4703317-4703559 [Microcystis aeruginosa]
MPNHCRIKNIVENMPDALKNELLHYAEYLLTKSDQTEENKQAAKESVTVKRTLAGSIKGTFVLPLANDFDAPLEDFEDYR

Download         Length: 243 bp

>AT38764 NZ_AP024565:4703317-4703559 [Microcystis aeruginosa]
ATGCCAAATCATTGCAGGATTAAGAATATAGTTGAGAATATGCCCGATGCTCTCAAAAATGAACTTTTACATTATGCCGA
ATATTTGCTCACTAAGTCTGACCAAACAGAAGAAAATAAACAAGCAGCAAAAGAATCCGTAACTGTTAAAAGAACTTTAG
CTGGTTCAATAAAAGGAACTTTCGTTTTACCTTTAGCTAATGACTTTGATGCTCCCTTAGAAGACTTTGAGGACTATAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References