Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-PHD |
| Location | 3664231..3664871 | Replicon | chromosome |
| Accession | NZ_AP024565 | ||
| Organism | Microcystis aeruginosa strain NIES-88 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | LC603172_RS18295 | Protein ID | WP_061430710.1 |
| Coordinates | 3664473..3664871 (+) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | I4ID84 |
| Locus tag | LC603172_RS18290 | Protein ID | WP_008201147.1 |
| Coordinates | 3664231..3664476 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LC603172_RS18255 (MAN88_35510) | 3659798..3660010 | - | 213 | WP_043996918.1 | DUF3148 domain-containing protein | - |
| LC603172_RS18260 (MAN88_35520) | 3660318..3660845 | + | 528 | Protein_3652 | IS630-like element ISMae25 family transposase | - |
| LC603172_RS18265 (MAN88_35530) | 3660908..3661702 | - | 795 | WP_061430706.1 | phytanoyl-CoA dioxygenase family protein | - |
| LC603172_RS18270 | 3662321..3662452 | + | 132 | WP_260324413.1 | hypothetical protein | - |
| LC603172_RS18275 (MAN88_35550) | 3662529..3662756 | - | 228 | WP_061430709.1 | hypothetical protein | - |
| LC603172_RS18280 (MAN88_35560) | 3663255..3663620 | - | 366 | WP_008205585.1 | clan AA aspartic protease | - |
| LC603172_RS18285 (MAN88_35570) | 3663617..3663892 | - | 276 | WP_002739245.1 | hypothetical protein | - |
| LC603172_RS18290 (MAN88_35580) | 3664231..3664476 | + | 246 | WP_008201147.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LC603172_RS18295 (MAN88_35590) | 3664473..3664871 | + | 399 | WP_061430710.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LC603172_RS28335 (MAN88_35600) | 3665334..3665456 | - | 123 | WP_260324414.1 | hypothetical protein | - |
| LC603172_RS28340 (MAN88_35610) | 3665479..3665655 | - | 177 | WP_072319580.1 | DUF4160 domain-containing protein | - |
| LC603172_RS18310 (MAN88_35620) | 3665804..3666547 | - | 744 | WP_061430711.1 | PEP-CTERM sorting domain-containing protein | - |
| LC603172_RS18315 (MAN88_35630) | 3666705..3667193 | + | 489 | WP_061430712.1 | hypothetical protein | - |
| LC603172_RS18320 (MAN88_35640) | 3667469..3667759 | + | 291 | WP_002757283.1 | nucleotidyltransferase | - |
| LC603172_RS18325 (MAN88_35650) | 3667749..3668099 | + | 351 | WP_061430713.1 | DUF86 domain-containing protein | - |
| LC603172_RS18330 (MAN88_35660) | 3668480..3669379 | + | 900 | WP_061431062.1 | agmatinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3660366..3660845 | 479 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14972.04 Da Isoelectric Point: 4.5069
>T38762 WP_061430710.1 NZ_AP024565:3664473-3664871 [Microcystis aeruginosa]
VRLLLDTQCWLWWFAQPDKLSENVIEQIANESNEVWFSVASVWEMGIKVSIGKLPLPEQIDNYVSTRMTQLGARSLEINA
SHALRAAALPLHHRDPFDRMLIAQAQVEDMTLVSADSTFNQYEVSLLWAASS
VRLLLDTQCWLWWFAQPDKLSENVIEQIANESNEVWFSVASVWEMGIKVSIGKLPLPEQIDNYVSTRMTQLGARSLEINA
SHALRAAALPLHHRDPFDRMLIAQAQVEDMTLVSADSTFNQYEVSLLWAASS
Download Length: 399 bp
>T38762 NZ_AP024565:3664473-3664871 [Microcystis aeruginosa]
GTGAGACTTTTACTGGATACACAATGCTGGCTGTGGTGGTTTGCCCAACCAGACAAGTTAAGTGAGAATGTAATTGAACA
AATTGCCAACGAAAGCAATGAAGTGTGGTTTTCTGTTGCCAGTGTTTGGGAGATGGGAATTAAAGTCTCAATCGGTAAAT
TACCACTGCCAGAGCAAATAGATAATTATGTCTCTACTCGAATGACTCAACTAGGAGCTAGATCGTTAGAGATCAATGCT
TCTCATGCTTTGCGGGCGGCTGCATTGCCTTTACATCATCGCGATCCTTTTGACAGAATGCTGATTGCACAAGCTCAGGT
AGAAGATATGACACTTGTGAGTGCGGATTCAACATTTAATCAATATGAAGTATCTTTGCTTTGGGCAGCTAGTTCTTAG
GTGAGACTTTTACTGGATACACAATGCTGGCTGTGGTGGTTTGCCCAACCAGACAAGTTAAGTGAGAATGTAATTGAACA
AATTGCCAACGAAAGCAATGAAGTGTGGTTTTCTGTTGCCAGTGTTTGGGAGATGGGAATTAAAGTCTCAATCGGTAAAT
TACCACTGCCAGAGCAAATAGATAATTATGTCTCTACTCGAATGACTCAACTAGGAGCTAGATCGTTAGAGATCAATGCT
TCTCATGCTTTGCGGGCGGCTGCATTGCCTTTACATCATCGCGATCCTTTTGACAGAATGCTGATTGCACAAGCTCAGGT
AGAAGATATGACACTTGTGAGTGCGGATTCAACATTTAATCAATATGAAGTATCTTTGCTTTGGGCAGCTAGTTCTTAG
Antitoxin
Download Length: 82 a.a. Molecular weight: 8950.20 Da Isoelectric Point: 4.7361
>AT38762 WP_008201147.1 NZ_AP024565:3664231-3664476 [Microcystis aeruginosa]
METVNIHQAKTNLSRLLSRVELGEEIVISNRGIPIAKLVPFRTSLDRRSSLGQDRGMFTVPDDFNAPLPEDILVAFEGGA
E
METVNIHQAKTNLSRLLSRVELGEEIVISNRGIPIAKLVPFRTSLDRRSSLGQDRGMFTVPDDFNAPLPEDILVAFEGGA
E
Download Length: 246 bp
>AT38762 NZ_AP024565:3664231-3664476 [Microcystis aeruginosa]
ATGGAAACTGTAAACATTCATCAGGCTAAAACAAACCTTTCTCGGCTATTGTCCCGTGTGGAACTCGGAGAGGAAATCGT
TATTTCAAACCGAGGTATTCCAATTGCTAAACTTGTTCCATTTCGGACATCTTTAGATCGACGGTCTAGTTTAGGACAAG
ATCGAGGGATGTTTACCGTACCAGATGATTTTAATGCTCCTTTACCAGAAGATATTTTGGTAGCATTTGAGGGTGGTGCG
GAGTGA
ATGGAAACTGTAAACATTCATCAGGCTAAAACAAACCTTTCTCGGCTATTGTCCCGTGTGGAACTCGGAGAGGAAATCGT
TATTTCAAACCGAGGTATTCCAATTGCTAAACTTGTTCCATTTCGGACATCTTTAGATCGACGGTCTAGTTTAGGACAAG
ATCGAGGGATGTTTACCGTACCAGATGATTTTAATGCTCCTTTACCAGAAGATATTTTGGTAGCATTTGAGGGTGGTGCG
GAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|