Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicA |
| Location | 2813864..2814270 | Replicon | chromosome |
| Accession | NZ_AP024565 | ||
| Organism | Microcystis aeruginosa strain NIES-88 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A3N0VX23 |
| Locus tag | LC603172_RS14080 | Protein ID | WP_024968900.1 |
| Coordinates | 2813864..2814061 (+) | Length | 66 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LC603172_RS14085 | Protein ID | WP_061430176.1 |
| Coordinates | 2814061..2814270 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LC603172_RS14045 (MAN88_27230) | 2809060..2809632 | + | 573 | WP_012265686.1 | manganese efflux pump MntP family protein | - |
| LC603172_RS14050 (MAN88_27240) | 2809659..2810351 | - | 693 | WP_061430170.1 | 7-cyano-7-deazaguanine synthase QueC | - |
| LC603172_RS14055 (MAN88_27250) | 2810351..2810713 | - | 363 | WP_061430171.1 | hypothetical protein | - |
| LC603172_RS14060 (MAN88_27260) | 2810710..2811027 | - | 318 | WP_061430172.1 | hypothetical protein | - |
| LC603172_RS14065 (MAN88_27270) | 2811304..2811921 | - | 618 | WP_061430173.1 | 7-carboxy-7-deazaguanine synthase QueE | - |
| LC603172_RS14070 (MAN88_27280) | 2811898..2812455 | + | 558 | WP_081106752.1 | Ycf51 family protein | - |
| LC603172_RS14075 (MAN88_27290) | 2812476..2813585 | + | 1110 | WP_061430175.1 | iron-containing alcohol dehydrogenase family protein | - |
| LC603172_RS14080 | 2813864..2814061 | + | 198 | WP_024968900.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LC603172_RS14085 (MAN88_27310) | 2814061..2814270 | + | 210 | WP_061430176.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LC603172_RS14090 | 2814311..2814367 | + | 57 | WP_239698008.1 | type II toxin-antitoxin system HigB family toxin | - |
| LC603172_RS14095 (MAN88_27320) | 2814396..2814617 | + | 222 | WP_061430177.1 | hypothetical protein | - |
| LC603172_RS14100 | 2814612..2814809 | - | 198 | WP_072319534.1 | transposase | - |
| LC603172_RS14110 (MAN88_27330) | 2815080..2816213 | + | 1134 | WP_061430178.1 | HetZ-related protein 2 | - |
| LC603172_RS14115 (MAN88_27340) | 2816359..2816517 | + | 159 | WP_170915472.1 | hypothetical protein | - |
| LC603172_RS14120 (MAN88_27350) | 2816520..2818034 | + | 1515 | WP_061430179.1 | cryptochrome/photolyase family protein | - |
| LC603172_RS14125 (MAN88_27360) | 2818157..2818498 | + | 342 | WP_061430180.1 | translation initiation factor | - |
| LC603172_RS14130 (MAN88_27370) | 2818508..2818975 | + | 468 | WP_061430181.1 | TspO/MBR family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2804772..2822975 | 18203 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 66 a.a. Molecular weight: 7350.47 Da Isoelectric Point: 10.6627
>T38760 WP_024968900.1 NZ_AP024565:2813864-2814061 [Microcystis aeruginosa]
MKVKQVIKVLEADGWYLARTRGSHRQYKHPSKSGTVTVSGKSSVDVPIGTLKNIWRQAQIEEDKI
MKVKQVIKVLEADGWYLARTRGSHRQYKHPSKSGTVTVSGKSSVDVPIGTLKNIWRQAQIEEDKI
Download Length: 198 bp
>T38760 NZ_AP024565:2813864-2814061 [Microcystis aeruginosa]
ATGAAAGTCAAACAAGTGATTAAAGTGTTAGAAGCGGATGGCTGGTATCTTGCTAGAACACGAGGAAGTCATAGGCAGTA
TAAACATCCCTCAAAATCTGGTACGGTAACGGTATCGGGGAAATCCAGCGTTGATGTTCCTATTGGGACTCTTAAAAATA
TATGGCGACAAGCTCAAATTGAGGAGGACAAAATATAA
ATGAAAGTCAAACAAGTGATTAAAGTGTTAGAAGCGGATGGCTGGTATCTTGCTAGAACACGAGGAAGTCATAGGCAGTA
TAAACATCCCTCAAAATCTGGTACGGTAACGGTATCGGGGAAATCCAGCGTTGATGTTCCTATTGGGACTCTTAAAAATA
TATGGCGACAAGCTCAAATTGAGGAGGACAAAATATAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 7499.58 Da Isoelectric Point: 3.8950
>AT38760 WP_061430176.1 NZ_AP024565:2814061-2814270 [Microcystis aeruginosa]
MRYAVVIEKGENSYGAYVPDLPGCVAVAETLEEVKQLIAEAIIFHLEGLKEDGLTVPESVSICEYIDVA
MRYAVVIEKGENSYGAYVPDLPGCVAVAETLEEVKQLIAEAIIFHLEGLKEDGLTVPESVSICEYIDVA
Download Length: 210 bp
>AT38760 NZ_AP024565:2814061-2814270 [Microcystis aeruginosa]
ATGCGATATGCAGTTGTTATTGAAAAAGGAGAAAATAGTTACGGTGCTTATGTTCCCGATCTTCCCGGTTGTGTTGCGGT
TGCAGAAACATTAGAAGAAGTTAAACAATTAATTGCTGAGGCAATAATTTTTCATTTGGAAGGCTTAAAAGAAGATGGAT
TAACTGTTCCTGAATCAGTGTCGATCTGTGAGTATATAGATGTAGCTTAG
ATGCGATATGCAGTTGTTATTGAAAAAGGAGAAAATAGTTACGGTGCTTATGTTCCCGATCTTCCCGGTTGTGTTGCGGT
TGCAGAAACATTAGAAGAAGTTAAACAATTAATTGCTGAGGCAATAATTTTTCATTTGGAAGGCTTAAAAGAAGATGGAT
TAACTGTTCCTGAATCAGTGTCGATCTGTGAGTATATAGATGTAGCTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|