Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1987695..1988476 | Replicon | chromosome |
| Accession | NZ_AP024565 | ||
| Organism | Microcystis aeruginosa strain NIES-88 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | L7E071 |
| Locus tag | LC603172_RS09830 | Protein ID | WP_002738857.1 |
| Coordinates | 1987695..1988189 (-) | Length | 165 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | I4GLR0 |
| Locus tag | LC603172_RS09835 | Protein ID | WP_002778803.1 |
| Coordinates | 1988186..1988476 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LC603172_RS09785 | 1983069..1983170 | + | 102 | Protein_1962 | DUF1349 domain-containing protein | - |
| LC603172_RS09790 (MAN88_19010) | 1983226..1983402 | + | 177 | Protein_1963 | ISL3 family transposase | - |
| LC603172_RS09795 (MAN88_19020) | 1983533..1983805 | - | 273 | WP_192846077.1 | transposase family protein | - |
| LC603172_RS09800 (MAN88_19030) | 1984663..1985349 | + | 687 | WP_239698231.1 | transposase | - |
| LC603172_RS09805 (MAN88_19040) | 1985587..1985859 | - | 273 | WP_061433361.1 | hypothetical protein | - |
| LC603172_RS09810 | 1985837..1986124 | - | 288 | Protein_1967 | BrnT family toxin | - |
| LC603172_RS09815 | 1986126..1986365 | - | 240 | WP_061433360.1 | hypothetical protein | - |
| LC603172_RS09820 (MAN88_19050) | 1986374..1986778 | + | 405 | WP_239698230.1 | nucleotidyltransferase domain-containing protein | - |
| LC603172_RS09825 (MAN88_19060) | 1986775..1987266 | + | 492 | WP_061433358.1 | hypothetical protein | - |
| LC603172_RS09830 (MAN88_19070) | 1987695..1988189 | - | 495 | WP_002738857.1 | GNAT family N-acetyltransferase | Toxin |
| LC603172_RS09835 (MAN88_19080) | 1988186..1988476 | - | 291 | WP_002778803.1 | DUF1778 domain-containing protein | Antitoxin |
| LC603172_RS09840 (MAN88_19090) | 1988868..1989140 | - | 273 | WP_061433357.1 | hypothetical protein | - |
| LC603172_RS09845 | 1989118..1989405 | - | 288 | Protein_1974 | BrnT family toxin | - |
| LC603172_RS09850 (MAN88_19100) | 1989629..1991440 | - | 1812 | WP_061433356.1 | hypothetical protein | - |
| LC603172_RS09855 (MAN88_19110) | 1991551..1992918 | - | 1368 | WP_061433355.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 165 a.a. Molecular weight: 17696.42 Da Isoelectric Point: 8.1174
>T38758 WP_002738857.1 NZ_AP024565:c1988189-1987695 [Microcystis aeruginosa]
MNLTPPEPLASYHSITDFSCGITSLDDWLKRRAYANQASGATRTFVTCVDNRVVGYYALASGAISIQSANGKFRRNMPNP
IPVVILARLAVDTSYQGQGLGCGLFRDGALRVVKAADTIGIRGIIVHAISEEAKNFYLALGFDVSPLEPMTLMITLNDLR
ACIA
MNLTPPEPLASYHSITDFSCGITSLDDWLKRRAYANQASGATRTFVTCVDNRVVGYYALASGAISIQSANGKFRRNMPNP
IPVVILARLAVDTSYQGQGLGCGLFRDGALRVVKAADTIGIRGIIVHAISEEAKNFYLALGFDVSPLEPMTLMITLNDLR
ACIA
Download Length: 495 bp
>T38758 NZ_AP024565:c1988189-1987695 [Microcystis aeruginosa]
ATGAATTTGACACCACCTGAACCTCTGGCTAGTTATCACTCAATCACTGATTTTTCCTGCGGAATTACTTCTCTTGATGA
TTGGTTGAAGCGTCGAGCTTATGCTAATCAAGCCAGTGGTGCAACTAGAACTTTTGTTACCTGCGTTGACAATAGGGTAG
TTGGGTATTACGCCCTTGCTTCCGGGGCGATTAGTATACAATCAGCTAATGGTAAATTTCGGCGGAATATGCCTAACCCA
ATTCCGGTGGTAATTTTGGCACGATTGGCAGTAGATACTTCTTACCAAGGTCAAGGTTTAGGATGCGGTTTATTTCGTGA
TGGTGCGCTACGGGTTGTTAAAGCGGCTGATACCATTGGTATTCGGGGAATTATTGTTCATGCTATTTCAGAAGAAGCTA
AGAATTTTTATTTGGCTTTAGGTTTTGATGTGTCTCCTCTTGAACCGATGACGTTGATGATTACTCTTAATGATTTACGC
GCTTGTATTGCTTAG
ATGAATTTGACACCACCTGAACCTCTGGCTAGTTATCACTCAATCACTGATTTTTCCTGCGGAATTACTTCTCTTGATGA
TTGGTTGAAGCGTCGAGCTTATGCTAATCAAGCCAGTGGTGCAACTAGAACTTTTGTTACCTGCGTTGACAATAGGGTAG
TTGGGTATTACGCCCTTGCTTCCGGGGCGATTAGTATACAATCAGCTAATGGTAAATTTCGGCGGAATATGCCTAACCCA
ATTCCGGTGGTAATTTTGGCACGATTGGCAGTAGATACTTCTTACCAAGGTCAAGGTTTAGGATGCGGTTTATTTCGTGA
TGGTGCGCTACGGGTTGTTAAAGCGGCTGATACCATTGGTATTCGGGGAATTATTGTTCATGCTATTTCAGAAGAAGCTA
AGAATTTTTATTTGGCTTTAGGTTTTGATGTGTCTCCTCTTGAACCGATGACGTTGATGATTACTCTTAATGATTTACGC
GCTTGTATTGCTTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 11041.66 Da Isoelectric Point: 9.7643
>AT38758 WP_002778803.1 NZ_AP024565:c1988476-1988186 [Microcystis aeruginosa]
MSSKTKSKTPRNTLNLRIKPEERNLIDMAAKVQGKNRTDFILEAARNAAEETLLERTIFWASPEAYAEFIALLDAPPQPN
ERLRKTMQTLAPWEKE
MSSKTKSKTPRNTLNLRIKPEERNLIDMAAKVQGKNRTDFILEAARNAAEETLLERTIFWASPEAYAEFIALLDAPPQPN
ERLRKTMQTLAPWEKE
Download Length: 291 bp
>AT38758 NZ_AP024565:c1988476-1988186 [Microcystis aeruginosa]
ATGAGTAGTAAAACAAAAAGTAAGACTCCGCGTAATACCCTAAATTTGCGAATTAAGCCAGAAGAACGCAATTTGATCGA
TATGGCAGCCAAAGTGCAAGGTAAGAATAGAACTGATTTTATTTTGGAAGCCGCGCGGAATGCTGCGGAGGAAACTTTGC
TCGAACGTACTATTTTTTGGGCTAGTCCAGAGGCTTATGCAGAATTTATCGCACTTCTAGATGCACCACCTCAACCTAAT
GAACGTTTACGCAAAACCATGCAGACGCTCGCACCTTGGGAGAAGGAATGA
ATGAGTAGTAAAACAAAAAGTAAGACTCCGCGTAATACCCTAAATTTGCGAATTAAGCCAGAAGAACGCAATTTGATCGA
TATGGCAGCCAAAGTGCAAGGTAAGAATAGAACTGATTTTATTTTGGAAGCCGCGCGGAATGCTGCGGAGGAAACTTTGC
TCGAACGTACTATTTTTTGGGCTAGTCCAGAGGCTTATGCAGAATTTATCGCACTTCTAGATGCACCACCTCAACCTAAT
GAACGTTTACGCAAAACCATGCAGACGCTCGCACCTTGGGAGAAGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|