Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 394493..395258 Replicon chromosome
Accession NZ_AP024565
Organism Microcystis aeruginosa strain NIES-88

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LC603172_RS02095 Protein ID WP_260324502.1
Coordinates 394830..395258 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LC603172_RS02090 Protein ID WP_002757103.1
Coordinates 394493..394837 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC603172_RS02055 (MAN88_04060) 389562..390428 - 867 WP_002757113.1 response regulator -
LC603172_RS02060 (MAN88_04070) 390728..391027 - 300 WP_061431989.1 (2Fe-2S) ferredoxin domain-containing protein -
LC603172_RS02065 (MAN88_04080) 391215..391916 + 702 WP_081106796.1 NnrU family protein -
LC603172_RS02070 (MAN88_04090) 392005..392346 + 342 WP_061432065.1 thioredoxin family protein -
LC603172_RS02075 (MAN88_04110) 392612..393268 + 657 WP_002757105.1 VWA domain-containing protein -
LC603172_RS02080 (MAN88_04120) 393282..394040 + 759 WP_061431990.1 PP2C family serine/threonine-protein phosphatase -
LC603172_RS02085 (MAN88_04130) 394112..394423 + 312 WP_061431991.1 nucleotidyltransferase family protein -
LC603172_RS02090 (MAN88_04140) 394493..394837 + 345 WP_002757103.1 hypothetical protein Antitoxin
LC603172_RS02095 (MAN88_04150) 394830..395258 + 429 WP_260324502.1 type II toxin-antitoxin system VapC family toxin Toxin
LC603172_RS02100 (MAN88_04160) 395559..397310 + 1752 WP_061431993.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
LC603172_RS02105 (MAN88_04170) 397698..398087 + 390 WP_002736777.1 nucleotidyltransferase family protein -
LC603172_RS02110 (MAN88_04180) 398074..398418 + 345 WP_061431994.1 DUF86 domain-containing protein -
LC603172_RS02115 (MAN88_04190) 398612..399598 + 987 WP_221275333.1 IS30-like element ISMae39 family transposase -
LC603172_RS02120 (MAN88_04200) 399643..399891 + 249 WP_081106797.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 388335..389522 1187
- flank IS/Tn - - 398612..399598 986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15987.34 Da        Isoelectric Point: 6.0781

>T38754 WP_260324502.1 NZ_AP024565:394830-395258 [Microcystis aeruginosa]
MIDTNIISELRKKSTANPGVLQFFQQAVEQSAPLYLSVITIGELRRGVDLIRHRGDQHQAELLETWLQTVLEDYTDHILD
FTALEAQVWGKLRVPNPHNALDKMIAATALTYGLILVTRNVSDFAGTGVPVLRYLVWFDRGA

Download         Length: 429 bp

>T38754 NZ_AP024565:394830-395258 [Microcystis aeruginosa]
TTGATTGATACTAATATTATTAGCGAATTGCGTAAAAAAAGCACAGCCAACCCCGGTGTCCTGCAATTTTTCCAGCAAGC
TGTCGAGCAATCCGCGCCGCTTTATCTTAGCGTTATCACTATTGGCGAACTGCGGCGAGGAGTTGACCTGATTCGACATC
GTGGCGACCAACACCAAGCCGAACTGTTAGAAACCTGGTTGCAGACTGTTTTGGAAGACTACACCGACCATATTCTAGAT
TTCACAGCACTTGAAGCCCAAGTTTGGGGCAAATTGCGCGTTCCCAATCCTCATAATGCTCTAGATAAAATGATCGCCGC
TACTGCACTCACCTACGGCTTAATCCTAGTCACCCGTAATGTGAGTGACTTCGCTGGCACAGGAGTTCCGGTTCTTCGTT
ACTTGGTATGGTTCGATAGGGGGGCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12833.40 Da        Isoelectric Point: 4.4742

>AT38754 WP_002757103.1 NZ_AP024565:394493-394837 [Microcystis aeruginosa]
MTDENIDYSDIPPLGDEFLTQETVSFSTSKQQLTIQPMADLIVRNIDEAIVKALKKRASQHGISAEAEHRQILEKALLQP
QRKSLAEVLRQIPNVGNDSDFDRVQDDTAKPVFD

Download         Length: 345 bp

>AT38754 NZ_AP024565:394493-394837 [Microcystis aeruginosa]
ATGACGGATGAGAATATCGATTATTCTGATATTCCGCCATTAGGTGATGAATTCCTTACCCAAGAAACAGTATCTTTTTC
GACATCAAAGCAGCAATTAACTATACAACCTATGGCAGATTTAATCGTCCGCAACATCGATGAAGCCATCGTCAAAGCTC
TCAAAAAGCGAGCCAGCCAACACGGGATCAGTGCCGAAGCCGAACACCGCCAAATCTTAGAAAAAGCCTTGCTGCAACCG
CAACGAAAATCCCTAGCAGAGGTGCTACGCCAGATTCCCAACGTTGGCAACGATTCAGACTTTGATCGCGTTCAAGATGA
CACAGCCAAACCAGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References