Detailed information of TA system TA038753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PrlF(antitoxin)
• Location: 2852976..2853546
• Replicon: chromosome
• Accession: NZ_AP024563
• Organism: Allochromatium tepidum strain NZ

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: Atep_RS13755
• Protein ID: WP_213379029.1
• Coordinates: 2852976..2853326 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: Atep_RS13760
• Protein ID: WP_213379030.1
• Coordinates: 2853316..2853546 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Atep_RS13725 (Atep_26610)	2849520..2849768	-	249	WP_213379026.1	DUF2442 domain-containing protein	-
Atep_RS13730 (Atep_26620)	2850180..2850995	+	816	WP_213379027.1	NYN domain-containing protein	-
Atep_RS13735 (Atep_26630)	2851020..2851763	-	744	WP_236786241.1	transposase	-
Atep_RS16940	2851786..2851884	-	99	Protein_2718	DUF4160 domain-containing protein	-
Atep_RS13745	2851997..2852515	-	519	Protein_2719	GNAT family N-acetyltransferase	-
Atep_RS13750 (Atep_26640)	2852512..2852790	-	279	WP_213379028.1	DUF1778 domain-containing protein	-
Atep_RS13755 (Atep_26650)	2852976..2853326	-	351	WP_213379029.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
Atep_RS13760 (Atep_26660)	2853316..2853546	-	231	WP_213379030.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
Atep_RS13765 (Atep_26670)	2854061..2854342	+	282	WP_213379031.1	hypothetical protein	-
Atep_RS13770 (Atep_26680)	2854329..2854649	+	321	WP_213379032.1	hypothetical protein	-
Atep_RS13775 (Atep_26690)	2855102..2855479	-	378	WP_213379033.1	MarR family transcriptional regulator	-
Atep_RS13780 (Atep_26700)	2855460..2855753	-	294	WP_213379034.1	DUF6516 family protein	-
Atep_RS13785	2855895..2856125	-	231	WP_213379035.1	hypothetical protein	-
Atep_RS13790 (Atep_26710)	2856122..2857378	-	1257	WP_213379036.1	glycosyltransferase	-
Atep_RS13795 (Atep_26720)	2857420..2858022	-	603	WP_213379037.1	methyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2847277..2861296	14019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-109)

Antitoxin

• PrlF antitoxin (5-47)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12506.52 Da
• Isoelectric Point: 8.0273

>T38753 WP_213379029.1 NZ_AP024563:c2853326-2852976 [Allochromatium tepidum]
VTFERFAVVRVPFPFTDRPAAKNRPALVLSDAALFNEPTGHAVMAMITSAANPPWAGDCPISDLQAAGLPAPSKVRFKLF
TLDLRLVRGQLGRLSAPDEAAVRLKLEQVLLSEDAP

Nucleotide

• Length: 351 bp

>T38753 NZ_AP024563:c2853326-2852976 [Allochromatium tepidum]
GTGACCTTTGAACGTTTCGCGGTCGTTCGCGTGCCGTTTCCCTTTACCGACCGGCCGGCCGCCAAGAACCGGCCGGCCTT
GGTGCTGTCCGATGCAGCGCTTTTCAATGAGCCGACCGGACATGCCGTGATGGCCATGATCACCTCGGCAGCCAATCCCC
CATGGGCCGGCGATTGCCCGATTAGCGACCTGCAAGCGGCTGGCCTGCCTGCGCCCTCCAAGGTGCGCTTCAAGCTGTTT
ACGCTGGACCTGCGTCTGGTGCGCGGCCAGTTGGGGCGGCTCTCCGCACCAGACGAAGCCGCAGTGCGGCTAAAGCTCGA
GCAGGTGCTGCTGTCGGAAGATGCGCCATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8296.38 Da
• Isoelectric Point: 4.7205

>AT38753 WP_213379030.1 NZ_AP024563:c2853546-2853316 [Allochromatium tepidum]
MIAIAKITAKGQTTIPQAVREMLHIKPGDAIAWEVNRDGTASVRRVDALDGQYLRALEGTLAEWSGAEDEAAYRDL

Nucleotide

• Length: 231 bp

>AT38753 NZ_AP024563:c2853546-2853316 [Allochromatium tepidum]
ATGATCGCGATAGCCAAGATTACCGCCAAAGGCCAGACGACGATACCGCAGGCGGTGCGCGAGATGCTCCACATCAAGCC
CGGCGACGCCATTGCCTGGGAAGTGAACCGTGACGGCACGGCCAGTGTCCGGCGCGTCGATGCGCTGGACGGACAATACC
TGCGCGCACTGGAAGGCACGCTTGCCGAATGGAGTGGCGCTGAAGACGAGGCGGCGTACCGTGACCTTTGA