Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2530588..2531224 Replicon chromosome
Accession NZ_AP024563
Organism Allochromatium tepidum strain NZ

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Atep_RS12180 Protein ID WP_213378769.1
Coordinates 2530588..2530980 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Atep_RS12185 Protein ID WP_213378770.1
Coordinates 2530967..2531224 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Atep_RS12160 (Atep_23630) 2526024..2527406 + 1383 WP_213378766.1 isochorismate synthase -
Atep_RS12165 (Atep_23640) 2527403..2529163 + 1761 WP_213378767.1 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase -
Atep_RS12170 (Atep_23650) 2529179..2529571 - 393 WP_213378768.1 PD-(D/E)XK nuclease domain-containing protein -
Atep_RS16730 (Atep_23660) 2529687..2530400 + 714 WP_236786191.1 hypothetical protein -
Atep_RS12180 (Atep_23670) 2530588..2530980 - 393 WP_213378769.1 type II toxin-antitoxin system VapC family toxin Toxin
Atep_RS12185 (Atep_23680) 2530967..2531224 - 258 WP_213378770.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
Atep_RS12190 (Atep_23690) 2531380..2532240 + 861 WP_213378771.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
Atep_RS12195 (Atep_23700) 2532283..2533182 + 900 WP_213378772.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
Atep_RS12200 (Atep_23710) 2533179..2534246 + 1068 WP_213378773.1 o-succinylbenzoate synthase -
Atep_RS12205 (Atep_23720) 2534306..2534848 - 543 WP_213378774.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14643.87 Da        Isoelectric Point: 6.7049

>T38752 WP_213378769.1 NZ_AP024563:c2530980-2530588 [Allochromatium tepidum]
MKTLDTNICSYILRRQPRSVLEYFRAQPAESFFLSALVVAELRFGVVKCGSTRLSVQLEDFLAGIPCRPWPEAATRHYAE
LRAVLERQGQPIGNMDMLIAAHALAEDAVLVTHNTREFERVPGLSVENWA

Download         Length: 393 bp

>T38752 NZ_AP024563:c2530980-2530588 [Allochromatium tepidum]
ATGAAGACACTTGATACCAACATCTGCAGCTACATCCTGCGCCGCCAGCCGCGTTCGGTGCTCGAGTATTTTCGCGCGCA
ACCGGCTGAGTCGTTCTTTCTCTCGGCGCTGGTCGTCGCAGAACTGCGCTTTGGTGTCGTCAAATGCGGTTCGACACGCT
TGAGCGTTCAACTGGAGGACTTTTTGGCGGGTATTCCGTGTCGGCCTTGGCCTGAGGCGGCCACGCGGCATTACGCCGAA
CTGCGTGCTGTACTGGAGCGCCAGGGTCAACCCATCGGCAACATGGACATGCTGATCGCCGCCCACGCGCTGGCCGAGGA
CGCCGTGCTGGTCACGCACAACACCCGCGAGTTCGAGCGCGTGCCGGGATTGAGCGTCGAAAATTGGGCGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10132.25 Da        Isoelectric Point: 4.5716

>AT38752 WP_213378770.1 NZ_AP024563:c2531224-2530967 [Allochromatium tepidum]
MRQTAKLFMNGRSQAVRLPAEFRFEGKEVYIERQGEAVILKPKAESLADWLESFYERHEPFPDDFLTDRQDTPPQDRAWF
HDEDT

Download         Length: 258 bp

>AT38752 NZ_AP024563:c2531224-2530967 [Allochromatium tepidum]
ATGCGTCAAACCGCCAAACTGTTCATGAACGGCCGCAGTCAGGCCGTGCGCCTGCCCGCCGAGTTCCGCTTCGAGGGCAA
GGAGGTGTACATCGAACGCCAGGGTGAGGCCGTCATCCTCAAGCCCAAGGCCGAGTCGCTCGCGGATTGGCTCGAATCCT
TCTATGAACGCCATGAACCCTTTCCCGATGATTTTCTGACCGACCGTCAGGATACCCCTCCACAAGACCGCGCTTGGTTT
CACGATGAAGACACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References