Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2174174..2174782 Replicon chromosome
Accession NZ_AP024563
Organism Allochromatium tepidum strain NZ

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Atep_RS10530 Protein ID WP_176977065.1
Coordinates 2174594..2174782 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Atep_RS10525 Protein ID WP_213378485.1
Coordinates 2174174..2174578 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Atep_RS10510 (Atep_20440) 2169365..2170288 - 924 WP_213378482.1 branched-chain amino acid transaminase -
Atep_RS10515 (Atep_20450) 2170373..2173225 - 2853 WP_213378483.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
Atep_RS10520 (Atep_20460) 2173249..2174163 - 915 WP_213378484.1 D-hexose-6-phosphate mutarotase -
Atep_RS10525 (Atep_20470) 2174174..2174578 - 405 WP_213378485.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Atep_RS10530 (Atep_20480) 2174594..2174782 - 189 WP_176977065.1 type II toxin-antitoxin system HicA family toxin Toxin
Atep_RS10535 (Atep_20490) 2174857..2177625 - 2769 WP_213378486.1 pyruvate, phosphate dikinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(2-121)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7111.30 Da        Isoelectric Point: 11.6157

>T38749 WP_176977065.1 NZ_AP024563:c2174782-2174594 [Allochromatium tepidum]
MKSGDVIKRLESDGWVLVRVKGSHHQFRRPGQPGLVTVPHPKTDIPLPTLRSIYRQAGWPWK

Download         Length: 189 bp

>T38749 NZ_AP024563:c2174782-2174594 [Allochromatium tepidum]
ATGAAAAGCGGCGATGTGATCAAGCGCCTGGAGTCCGACGGCTGGGTGCTGGTGCGCGTGAAAGGCTCGCATCATCAGTT
CCGGCGGCCCGGACAGCCGGGATTGGTCACGGTGCCGCATCCGAAAACCGATATTCCGCTGCCGACCCTGCGCAGCATCT
ACCGTCAGGCCGGCTGGCCCTGGAAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14673.51 Da        Isoelectric Point: 4.9263

>AT38749 WP_213378485.1 NZ_AP024563:c2174578-2174174 [Allochromatium tepidum]
MALHTDDGVTYGVTVPDLPGCFSAGESLDQAIENAYEAIDAHVELLMDDGDAVPCPRPLAEHQSNPDFAGAVWVVIDAPI
ERYFGPTEKIHIRVPRRLLQRIDAHAKARHLSRSAFLTQVASEAMGREGPCRNQ

Download         Length: 405 bp

>AT38749 NZ_AP024563:c2174578-2174174 [Allochromatium tepidum]
TTGGCCCTACATACTGATGATGGTGTGACCTATGGGGTCACGGTGCCCGATCTTCCGGGGTGTTTCTCGGCGGGTGAGAG
TCTGGATCAGGCGATCGAGAACGCTTACGAGGCGATCGATGCCCATGTCGAGTTGCTGATGGATGATGGAGACGCCGTCC
CCTGTCCGCGCCCGCTCGCCGAGCATCAGTCCAATCCGGATTTCGCCGGGGCGGTGTGGGTGGTGATCGATGCGCCGATC
GAGCGCTATTTCGGACCGACCGAGAAGATCCATATCCGGGTGCCGCGACGGTTGCTCCAGCGCATCGATGCGCATGCCAA
GGCTCGTCATCTGAGCCGTTCGGCCTTTCTGACCCAGGTCGCTAGCGAGGCGATGGGGCGCGAAGGGCCATGCCGGAACC
AATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References