Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1449783..1450615 | Replicon | chromosome |
| Accession | NZ_AP024561 | ||
| Organism | Escherichia coli strain NIPH17_0036 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | FLY99_RS07025 | Protein ID | WP_000854765.1 |
| Coordinates | 1450241..1450615 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | FLY99_RS07020 | Protein ID | WP_001295723.1 |
| Coordinates | 1449783..1450151 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FLY99_RS06985 (1445451) | 1445451..1446131 | + | 681 | WP_001282921.1 | WYL domain-containing protein | - |
| FLY99_RS06990 (1446279) | 1446279..1446956 | + | 678 | WP_001097302.1 | hypothetical protein | - |
| FLY99_RS06995 (1446962) | 1446962..1447195 | + | 234 | WP_001278293.1 | DUF905 family protein | - |
| FLY99_RS07000 (1447285) | 1447285..1448103 | + | 819 | WP_001175165.1 | DUF932 domain-containing protein | - |
| FLY99_RS07005 (1448369) | 1448369..1448848 | + | 480 | WP_057109541.1 | antirestriction protein | - |
| FLY99_RS07010 (1448864) | 1448864..1449340 | + | 477 | WP_001186774.1 | RadC family protein | - |
| FLY99_RS07015 (1449403) | 1449403..1449624 | + | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| FLY99_RS07020 (1449783) | 1449783..1450151 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FLY99_RS07025 (1450241) | 1450241..1450615 | + | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| FLY99_RS07030 (1450615) | 1450615..1450818 | + | 204 | WP_001398797.1 | DUF5983 family protein | - |
| FLY99_RS07035 (1450843) | 1450843..1451037 | + | 195 | WP_024181941.1 | DUF957 domain-containing protein | - |
| FLY99_RS07040 (1451122) | 1451122..1451964 | + | 843 | WP_022645115.1 | DUF4942 domain-containing protein | - |
| FLY99_RS07045 (1452246) | 1452246..1452782 | - | 537 | WP_000942786.1 | GspM family type II secretion system protein YghD | - |
| FLY99_RS07050 (1452784) | 1452784..1453962 | - | 1179 | WP_000094970.1 | type II secretion system protein GspL | - |
| FLY99_RS07055 (1453959) | 1453959..1454936 | - | 978 | WP_000633220.1 | type II secretion system minor pseudopilin GspK | - |
| FLY99_RS07060 (1454939) | 1454939..1455142 | - | 204 | Protein_1386 | type II secretion system protein GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T38738 WP_000854765.1 NZ_AP024561:1450241-1450615 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T38738 NZ_AP024561:1450241-1450615 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT38738 WP_001295723.1 NZ_AP024561:1449783-1450151 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT38738 NZ_AP024561:1449783-1450151 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|