Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3916467..3917311 Replicon chromosome
Accession NZ_AP024560
Organism Escherichia coli strain NIPH17_0020

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag FLY91_RS18875 Protein ID WP_000854686.1
Coordinates 3916467..3916850 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FLY91_RS18880 Protein ID WP_141305810.1
Coordinates 3916931..3917311 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLY91_RS18835 (3911470) 3911470..3911961 - 492 WP_001297187.1 DUF1097 domain-containing protein -
FLY91_RS18840 (3912063) 3912063..3912617 - 555 WP_001001902.1 molecular chaperone YcdY -
FLY91_RS18845 (3912641) 3912641..3913378 - 738 WP_000283664.1 zinc-binding phosphatase -
FLY91_RS18850 (3913433) 3913433..3914371 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
FLY91_RS18860 (3914842) 3914842..3915683 - 842 Protein_3720 DUF4942 domain-containing protein -
FLY91_RS18865 (3915768) 3915768..3915965 - 198 WP_000839253.1 DUF957 domain-containing protein -
FLY91_RS18870 (3915982) 3915982..3916470 - 489 WP_032180032.1 DUF5983 family protein -
FLY91_RS18875 (3916467) 3916467..3916850 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
FLY91_RS18880 (3916931) 3916931..3917311 - 381 WP_141305810.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FLY91_RS18885 (3917322) 3917322..3918005 - 684 WP_000086768.1 hypothetical protein -
FLY91_RS18890 (3918024) 3918024..3918245 - 222 WP_000692298.1 DUF987 domain-containing protein -
FLY91_RS18895 (3918308) 3918308..3918784 - 477 WP_001186726.1 RadC family protein -
FLY91_RS18900 (3918800) 3918800..3919285 - 486 WP_000214307.1 antirestriction protein -
FLY91_RS18905 (3919377) 3919377..3920198 - 822 WP_001761104.1 DUF932 domain-containing protein -
FLY91_RS18910 (3920299) 3920299..3920507 - 209 Protein_3730 DUF905 family protein -
FLY91_RS18915 (3920608) 3920608..3921063 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T38722 WP_000854686.1 NZ_AP024560:c3916850-3916467 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T38722 NZ_AP024560:c3916850-3916467 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13970.75 Da        Isoelectric Point: 5.0823

>AT38722 WP_141305810.1 NZ_AP024560:c3917311-3916931 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTMTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT38722 NZ_AP024560:c3917311-3916931 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCATGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References