Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 51645..52173 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K6J79_RS14245 Protein ID WP_000221352.1
Coordinates 51645..51935 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K6J79_RS14250 Protein ID WP_000213183.1
Coordinates 51925..52173 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J79_RS18975 46915..47025 + 111 WP_134814058.1 DUF3265 domain-containing protein -
K6J79_RS18980 47064..47174 + 111 Protein_102 acetyltransferase -
K6J79_RS14210 47202..47327 + 126 WP_001944767.1 DUF645 family protein -
K6J79_RS18985 47290..47406 + 117 WP_001889170.1 hypothetical protein -
K6J79_RS14220 47594..48598 + 1005 WP_000964925.1 LD-carboxypeptidase -
K6J79_RS14225 48751..49197 + 447 WP_000128977.1 hypothetical protein -
K6J79_RS14230 49317..50246 + 930 WP_000335802.1 hypothetical protein -
K6J79_RS18990 50243..50353 + 111 WP_071917832.1 DUF3265 domain-containing protein -
K6J79_RS14235 50381..50857 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
K6J79_RS14240 51048..51509 + 462 WP_001911752.1 lipocalin family protein -
K6J79_RS14245 51645..51935 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J79_RS14250 51925..52173 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J79_RS14255 52744..53397 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
K6J79_RS14260 53669..54094 + 426 WP_000415748.1 hypothetical protein -
K6J79_RS14265 54302..54697 + 396 WP_000649527.1 DUF3465 domain-containing protein -
K6J79_RS14270 54848..55378 + 531 WP_000415563.1 hypothetical protein -
K6J79_RS14275 55516..56016 + 501 WP_000789723.1 hypothetical protein -
K6J79_RS14280 56172..56570 + 399 WP_001882293.1 hypothetical protein -
K6J79_RS14285 56670..57134 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA 3..1061958 1061955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T38694 WP_000221352.1 NZ_AP024556:c51935-51645 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T38694 NZ_AP024556:c51935-51645 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT38694 WP_000213183.1 NZ_AP024556:c52173-51925 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT38694 NZ_AP024556:c52173-51925 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References