38692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 42228..42806 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J79_RS14165 Protein ID WP_001180243.1
Coordinates 42228..42545 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J79_RS14170 Protein ID WP_000557292.1
Coordinates 42564..42806 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J79_RS14120 37419..37814 + 396 WP_000046952.1 DUF6404 family protein -
K6J79_RS18935 37913..38056 + 144 Protein_78 acetyltransferase -
K6J79_RS14125 38179..38298 + 120 WP_001900954.1 DUF645 family protein -
K6J79_RS14130 38475..38870 + 396 WP_000046953.1 DUF6404 family protein -
K6J79_RS14135 39014..39550 + 537 WP_000644491.1 nucleotidyltransferase family protein -
K6J79_RS18940 39901..39963 + 63 Protein_82 DUF645 family protein -
K6J79_RS18945 39953..40063 + 111 WP_223804330.1 Tfp pilus assembly protein -
K6J79_RS14145 40222..40647 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
K6J79_RS14150 40796..41143 + 348 WP_000933409.1 hypothetical protein -
K6J79_RS14155 41290..41583 + 294 WP_125460920.1 hypothetical protein -
K6J79_RS18950 41646..41821 + 176 Protein_87 acetyltransferase -
K6J79_RS18955 41882..42034 + 153 Protein_88 DUF645 family protein -
K6J79_RS14165 42228..42545 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J79_RS14170 42564..42806 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J79_RS14175 43048..43557 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
K6J79_RS14180 43614..44267 + 654 WP_000226874.1 hypothetical protein -
K6J79_RS18960 44356..44565 + 210 WP_001900246.1 DUF3709 domain-containing protein -
K6J79_RS14185 44577..44795 + 219 WP_001917086.1 DUF3709 domain-containing protein -
K6J79_RS18965 44984..45177 + 194 Protein_95 hypothetical protein -
K6J79_RS14190 45198..45431 + 234 WP_032482776.1 DUF3709 domain-containing protein -
K6J79_RS14195 45856..46036 + 181 Protein_97 DUF645 family protein -
K6J79_RS18970 46149..46262 + 114 WP_001894955.1 hypothetical protein -
K6J79_RS14200 46303..46590 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J79_RS14205 46601..46918 + 318 WP_001232701.1 HigA family addiction module antitoxin -
K6J79_RS18975 46915..47025 + 111 WP_134814058.1 DUF3265 domain-containing protein -
K6J79_RS18980 47064..47174 + 111 Protein_102 acetyltransferase -
K6J79_RS14210 47202..47327 + 126 WP_001944767.1 DUF645 family protein -
K6J79_RS18985 47290..47406 + 117 WP_001889170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA 3..1061958 1061955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38692 WP_001180243.1 NZ_AP024556:c42545-42228 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38692 NZ_AP024556:c42545-42228 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38692 WP_000557292.1 NZ_AP024556:c42806-42564 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38692 NZ_AP024556:c42806-42564 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References