Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 26506..27044 | Replicon | chromosome |
| Accession | NZ_AP024556 | ||
| Organism | Vibrio cholerae strain IDH-03506 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | K6J79_RS14040 | Protein ID | WP_000802136.1 |
| Coordinates | 26506..26805 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | K6J79_RS14045 | Protein ID | WP_001107719.1 |
| Coordinates | 26802..27044 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J79_RS18925 | 22243..22380 | + | 138 | WP_001890145.1 | hypothetical protein | - |
| K6J79_RS14000 | 22441..22623 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| K6J79_RS14005 | 22823..23296 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| K6J79_RS14010 | 23311..23403 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| K6J79_RS14015 | 23445..24071 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| K6J79_RS14020 | 24194..24892 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| K6J79_RS14025 | 24923..25012 | + | 90 | WP_072606010.1 | DUF3265 domain-containing protein | - |
| K6J79_RS14030 | 25590..25769 | + | 180 | WP_001883058.1 | DUF645 family protein | - |
| K6J79_RS14035 | 25983..26378 | + | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
| K6J79_RS14040 | 26506..26805 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6J79_RS14045 | 26802..27044 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| K6J79_RS14050 | 27273..27851 | + | 579 | WP_000110120.1 | hypothetical protein | - |
| K6J79_RS14055 | 27873..27965 | + | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| K6J79_RS14060 | 28389..29072 | + | 684 | WP_000877436.1 | hypothetical protein | - |
| K6J79_RS14065 | 29286..29552 | + | 267 | WP_000937852.1 | hypothetical protein | - |
| K6J79_RS14070 | 29707..30306 | + | 600 | WP_000429495.1 | DUF6338 family protein | - |
| K6J79_RS14075 | 30587..31522 | + | 936 | WP_000051985.1 | restriction endonuclease | - |
| K6J79_RS14080 | 31488..31628 | + | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA | 3..1061958 | 1061955 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T38691 WP_000802136.1 NZ_AP024556:c26805-26506 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T38691 NZ_AP024556:c26805-26506 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT38691 WP_001107719.1 NZ_AP024556:c27044-26802 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT38691 NZ_AP024556:c27044-26802 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A | |
| PDB | 7B22 | |
| AlphaFold DB | A0A151JFU4 |