Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 20119..20678 | Replicon | chromosome |
| Accession | NZ_AP024556 | ||
| Organism | Vibrio cholerae strain IDH-03506 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | K6J79_RS13980 | Protein ID | WP_000578476.1 |
| Coordinates | 20119..20397 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | K6J79_RS13985 | Protein ID | WP_000381183.1 |
| Coordinates | 20394..20678 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J79_RS13940 | 15197..15703 | + | 507 | WP_000393074.1 | hypothetical protein | - |
| K6J79_RS13945 | 15860..16246 | + | 387 | WP_000703163.1 | VOC family protein | - |
| K6J79_RS13950 | 16503..16706 | + | 204 | WP_001911580.1 | hypothetical protein | - |
| K6J79_RS13955 | 16901..17152 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| K6J79_RS18915 | 17125..17274 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| K6J79_RS13960 | 17421..17846 | + | 426 | WP_000415750.1 | hypothetical protein | - |
| K6J79_RS13965 | 18052..18675 | + | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| K6J79_RS13970 | 18888..19367 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| K6J79_RS18920 | 19364..19480 | + | 117 | WP_086010882.1 | DUF3265 domain-containing protein | - |
| K6J79_RS13975 | 19555..19968 | + | 414 | WP_000049420.1 | VOC family protein | - |
| K6J79_RS13980 | 20119..20397 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| K6J79_RS13985 | 20394..20678 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K6J79_RS13990 | 20927..21388 | + | 462 | WP_001911578.1 | lipocalin family protein | - |
| K6J79_RS13995 | 21453..22049 | + | 597 | WP_000255434.1 | hypothetical protein | - |
| K6J79_RS18925 | 22243..22380 | + | 138 | WP_001890145.1 | hypothetical protein | - |
| K6J79_RS14000 | 22441..22623 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| K6J79_RS14005 | 22823..23296 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| K6J79_RS14010 | 23311..23403 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| K6J79_RS14015 | 23445..24071 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| K6J79_RS14020 | 24194..24892 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| K6J79_RS14025 | 24923..25012 | + | 90 | WP_072606010.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA | 3..1061958 | 1061955 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T38690 WP_000578476.1 NZ_AP024556:c20397-20119 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T38690 NZ_AP024556:c20397-20119 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT38690 WP_000381183.1 NZ_AP024556:c20678-20394 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT38690 NZ_AP024556:c20678-20394 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |