Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 10829..11327 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag K6J79_RS13900 Protein ID WP_000589156.1
Coordinates 10829..11095 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag K6J79_RS13905 Protein ID WP_000643598.1
Coordinates 11082..11327 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J79_RS18870 6358..6456 + 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J79_RS13855 6656..6757 + 102 WP_001921603.1 hypothetical protein -
K6J79_RS13860 6747..7133 + 387 WP_000703163.1 VOC family protein -
K6J79_RS13865 7328..7579 + 252 WP_001890111.1 TIGR03643 family protein -
K6J79_RS18875 7552..7701 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J79_RS13870 7793..8035 + 243 WP_000107461.1 hypothetical protein -
K6J79_RS13875 8287..8565 + 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J79_RS18880 8997..9040 + 44 Protein_22 hypothetical protein -
K6J79_RS18885 9022..9115 + 94 Protein_23 ggdef family protein -
K6J79_RS18890 9084..9215 + 132 WP_001883067.1 hypothetical protein -
K6J79_RS13890 9387..9854 + 468 WP_001289288.1 OsmC family protein -
K6J79_RS13895 9982..10644 + 663 WP_000960654.1 hypothetical protein -
K6J79_RS18895 10634..10762 + 129 WP_088124358.1 DUF3265 domain-containing protein -
K6J79_RS13900 10829..11095 + 267 WP_000589156.1 BrnT family toxin Toxin
K6J79_RS13905 11082..11327 + 246 WP_000643598.1 hypothetical protein Antitoxin
K6J79_RS13910 11423..12217 + 795 WP_001911581.1 hypothetical protein -
K6J79_RS18900 12214..12330 + 117 WP_086010881.1 DUF3265 domain-containing protein -
K6J79_RS13915 12320..12448 + 129 WP_071908338.1 general secretion pathway protein GspI -
K6J79_RS13920 12509..12691 + 183 WP_000923182.1 DUF645 family protein -
K6J79_RS13925 12907..13911 + 1005 WP_000964920.1 LD-carboxypeptidase -
K6J79_RS13930 14064..14423 + 360 WP_001071541.1 VOC family protein -
K6J79_RS18905 14490..14675 + 186 WP_001999468.1 hypothetical protein -
K6J79_RS18910 14807..14929 + 123 WP_001937972.1 DUF3709 domain-containing protein -
K6J79_RS13940 15197..15703 + 507 WP_000393074.1 hypothetical protein -
K6J79_RS13945 15860..16246 + 387 WP_000703163.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA 3..1061958 1061955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T38689 WP_000589156.1 NZ_AP024556:10829-11095 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T38689 NZ_AP024556:10829-11095 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT38689 WP_000643598.1 NZ_AP024556:11082-11327 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT38689 NZ_AP024556:11082-11327 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References