Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 761068..761647 | Replicon | chromosome |
| Accession | NZ_AP024552 | ||
| Organism | Vibrio cholerae strain IDH-02387 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | K6J81_RS17855 | Protein ID | WP_001180243.1 |
| Coordinates | 761330..761647 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | K6J81_RS17850 | Protein ID | WP_221291565.1 |
| Coordinates | 761068..761340 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J81_RS17800 | 756463..756908 | - | 446 | Protein_741 | hypothetical protein | - |
| K6J81_RS17810 | 757158..757283 | - | 126 | WP_001900195.1 | DUF645 family protein | - |
| K6J81_RS17815 | 757676..757948 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| K6J81_RS17820 | 757945..758442 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| K6J81_RS19380 | 758459..758527 | - | 69 | Protein_745 | acetyltransferase | - |
| K6J81_RS17825 | 758592..759053 | - | 462 | WP_001903091.1 | lipocalin family protein | - |
| K6J81_RS17830 | 759244..759780 | - | 537 | WP_000469482.1 | GNAT family protein | - |
| K6J81_RS17835 | 760038..760259 | - | 222 | WP_032467793.1 | DUF1289 domain-containing protein | - |
| K6J81_RS17840 | 760268..760381 | - | 114 | WP_001900214.1 | hypothetical protein | - |
| K6J81_RS17845 | 760438..760824 | - | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| K6J81_RS17850 | 761068..761340 | + | 273 | WP_221291565.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6J81_RS17855 | 761330..761647 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6J81_RS17860 | 761801..762139 | - | 339 | WP_000713853.1 | hypothetical protein | - |
| K6J81_RS17865 | 762297..763001 | - | 705 | WP_000087610.1 | HNH endonuclease | - |
| K6J81_RS17870 | 763163..764371 | - | 1209 | WP_000272282.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| K6J81_RS17875 | 764533..765210 | - | 678 | WP_000254617.1 | HNH endonuclease signature motif containing protein | - |
| K6J81_RS17880 | 765405..765587 | - | 183 | WP_000923153.1 | DUF645 family protein | - |
| K6J81_RS19385 | 765759..765821 | - | 63 | Protein_758 | acetyltransferase | - |
| K6J81_RS17885 | 765941..766123 | - | 183 | WP_000923340.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 730402..773207 | 42805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T38665 WP_001180243.1 NZ_AP024552:761330-761647 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T38665 NZ_AP024552:761330-761647 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 10181.69 Da Isoelectric Point: 7.2770
>AT38665 WP_221291565.1 NZ_AP024552:761068-761340 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFSKHP
LIERLPQYAK
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFSKHP
LIERLPQYAK
Download Length: 273 bp
>AT38665 NZ_AP024552:761068-761340 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTTCTAAACACCCT
TTGATTGAGCGTTTACCTCAATATGCAAAATAA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTTCTAAACACCCT
TTGATTGAGCGTTTACCTCAATATGCAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|