38664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 757676..758442 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J81_RS17820 Protein ID WP_000982260.1
Coordinates 757945..758442 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J81_RS17815 Protein ID WP_000246253.1
Coordinates 757676..757948 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J81_RS17760 753174..753416 - 243 WP_000107461.1 hypothetical protein -
K6J81_RS19365 753508..753657 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J81_RS17765 753630..753881 - 252 WP_001890111.1 TIGR03643 family protein -
K6J81_RS17770 754076..754462 - 387 WP_000703163.1 VOC family protein -
K6J81_RS17775 754452..754553 - 102 WP_001921603.1 hypothetical protein -
K6J81_RS19370 754753..754851 - 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J81_RS17785 755211..755489 - 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J81_RS19375 755607..755724 - 118 Protein_738 DUF3265 domain-containing protein -
K6J81_RS17790 755775..756053 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J81_RS17795 756046..756315 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
K6J81_RS17800 756463..756908 - 446 Protein_741 hypothetical protein -
K6J81_RS17810 757158..757283 - 126 WP_001900195.1 DUF645 family protein -
K6J81_RS17815 757676..757948 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K6J81_RS17820 757945..758442 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K6J81_RS19380 758459..758527 - 69 Protein_745 acetyltransferase -
K6J81_RS17825 758592..759053 - 462 WP_001903091.1 lipocalin family protein -
K6J81_RS17830 759244..759780 - 537 WP_000469482.1 GNAT family protein -
K6J81_RS17835 760038..760259 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J81_RS17840 760268..760381 - 114 WP_001900214.1 hypothetical protein -
K6J81_RS17845 760438..760824 - 387 WP_001015867.1 NUDIX hydrolase -
K6J81_RS17850 761068..761340 + 273 WP_221291565.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J81_RS17855 761330..761647 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J81_RS17860 761801..762139 - 339 WP_000713853.1 hypothetical protein -
K6J81_RS17865 762297..763001 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 730402..773207 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38664 WP_000982260.1 NZ_AP024552:757945-758442 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38664 NZ_AP024552:757945-758442 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38664 WP_000246253.1 NZ_AP024552:757676-757948 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38664 NZ_AP024552:757676-757948 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References