38663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 755775..756315 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag K6J81_RS17795 Protein ID WP_000277238.1
Coordinates 756046..756315 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag K6J81_RS17790 Protein ID WP_001258569.1
Coordinates 755775..756053 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J81_RS19360 750834..750950 - 117 WP_086010881.1 DUF3265 domain-containing protein -
K6J81_RS17740 750947..751741 - 795 WP_001911581.1 hypothetical protein -
K6J81_RS17745 751837..752082 - 246 WP_000643598.1 hypothetical protein -
K6J81_RS17750 752069..752335 - 267 WP_000589156.1 BrnT family toxin -
K6J81_RS17755 752644..752922 - 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J81_RS17760 753174..753416 - 243 WP_000107461.1 hypothetical protein -
K6J81_RS19365 753508..753657 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J81_RS17765 753630..753881 - 252 WP_001890111.1 TIGR03643 family protein -
K6J81_RS17770 754076..754462 - 387 WP_000703163.1 VOC family protein -
K6J81_RS17775 754452..754553 - 102 WP_001921603.1 hypothetical protein -
K6J81_RS19370 754753..754851 - 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J81_RS17785 755211..755489 - 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J81_RS19375 755607..755724 - 118 Protein_738 DUF3265 domain-containing protein -
K6J81_RS17790 755775..756053 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J81_RS17795 756046..756315 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J81_RS17800 756463..756908 - 446 Protein_741 hypothetical protein -
K6J81_RS17810 757158..757283 - 126 WP_001900195.1 DUF645 family protein -
K6J81_RS17815 757676..757948 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J81_RS17820 757945..758442 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J81_RS19380 758459..758527 - 69 Protein_745 acetyltransferase -
K6J81_RS17825 758592..759053 - 462 WP_001903091.1 lipocalin family protein -
K6J81_RS17830 759244..759780 - 537 WP_000469482.1 GNAT family protein -
K6J81_RS17835 760038..760259 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J81_RS17840 760268..760381 - 114 WP_001900214.1 hypothetical protein -
K6J81_RS17845 760438..760824 - 387 WP_001015867.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 730402..773207 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T38663 WP_000277238.1 NZ_AP024552:756046-756315 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T38663 NZ_AP024552:756046-756315 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT38663 WP_001258569.1 NZ_AP024552:755775-756053 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT38663 NZ_AP024552:755775-756053 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References