Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /BrnT(toxin) |
| Location | 751837..752335 | Replicon | chromosome |
| Accession | NZ_AP024552 | ||
| Organism | Vibrio cholerae strain IDH-02387 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK7 |
| Locus tag | K6J81_RS17750 | Protein ID | WP_000589156.1 |
| Coordinates | 752069..752335 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK6 |
| Locus tag | K6J81_RS17745 | Protein ID | WP_000643598.1 |
| Coordinates | 751837..752082 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J81_RS17705 | 746918..747304 | - | 387 | WP_000703163.1 | VOC family protein | - |
| K6J81_RS17710 | 747461..747967 | - | 507 | WP_000393074.1 | hypothetical protein | - |
| K6J81_RS19355 | 748489..748674 | - | 186 | WP_001999468.1 | hypothetical protein | - |
| K6J81_RS17720 | 748741..749100 | - | 360 | WP_001071541.1 | VOC family protein | - |
| K6J81_RS17725 | 749253..750257 | - | 1005 | WP_000964920.1 | LD-carboxypeptidase | - |
| K6J81_RS17730 | 750473..750655 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
| K6J81_RS17735 | 750716..750844 | - | 129 | WP_071908338.1 | general secretion pathway protein GspI | - |
| K6J81_RS19360 | 750834..750950 | - | 117 | WP_086010881.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17740 | 750947..751741 | - | 795 | WP_001911581.1 | hypothetical protein | - |
| K6J81_RS17745 | 751837..752082 | - | 246 | WP_000643598.1 | hypothetical protein | Antitoxin |
| K6J81_RS17750 | 752069..752335 | - | 267 | WP_000589156.1 | BrnT family toxin | Toxin |
| K6J81_RS17755 | 752644..752922 | - | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| K6J81_RS17760 | 753174..753416 | - | 243 | WP_000107461.1 | hypothetical protein | - |
| K6J81_RS19365 | 753508..753657 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17765 | 753630..753881 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| K6J81_RS17770 | 754076..754462 | - | 387 | WP_000703163.1 | VOC family protein | - |
| K6J81_RS17775 | 754452..754553 | - | 102 | WP_001921603.1 | hypothetical protein | - |
| K6J81_RS19370 | 754753..754851 | - | 99 | WP_223225486.1 | DUF3709 domain-containing protein | - |
| K6J81_RS17785 | 755211..755489 | - | 279 | WP_001921601.1 | DUF3709 domain-containing protein | - |
| K6J81_RS19375 | 755607..755724 | - | 118 | Protein_738 | DUF3265 domain-containing protein | - |
| K6J81_RS17790 | 755775..756053 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| K6J81_RS17795 | 756046..756315 | + | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
| K6J81_RS17800 | 756463..756908 | - | 446 | Protein_741 | hypothetical protein | - |
| K6J81_RS17810 | 757158..757283 | - | 126 | WP_001900195.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 730402..773207 | 42805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10092.34 Da Isoelectric Point: 7.3171
>T38662 WP_000589156.1 NZ_AP024552:c752335-752069 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
Download Length: 267 bp
>T38662 NZ_AP024552:c752335-752069 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9478.77 Da Isoelectric Point: 6.4832
>AT38662 WP_000643598.1 NZ_AP024552:c752082-751837 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
Download Length: 246 bp
>AT38662 NZ_AP024552:c752082-751837 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VMP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VME2 |