Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 742486..743045 | Replicon | chromosome |
| Accession | NZ_AP024552 | ||
| Organism | Vibrio cholerae strain IDH-02387 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | K6J81_RS17670 | Protein ID | WP_000578476.1 |
| Coordinates | 742767..743045 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | K6J81_RS17665 | Protein ID | WP_000381183.1 |
| Coordinates | 742486..742770 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J81_RS17625 | 738152..738241 | - | 90 | WP_072606010.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17630 | 738272..738970 | - | 699 | WP_001890502.1 | hypothetical protein | - |
| K6J81_RS17635 | 739093..739719 | - | 627 | WP_000365424.1 | LysE family translocator | - |
| K6J81_RS17640 | 739761..739853 | - | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17645 | 739868..740341 | - | 474 | WP_001161076.1 | GrpB family protein | - |
| K6J81_RS17650 | 740541..740723 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
| K6J81_RS19340 | 740784..740921 | - | 138 | WP_001890145.1 | hypothetical protein | - |
| K6J81_RS17655 | 741115..741711 | - | 597 | WP_000255434.1 | hypothetical protein | - |
| K6J81_RS17660 | 741776..742237 | - | 462 | WP_001911578.1 | lipocalin family protein | - |
| K6J81_RS17665 | 742486..742770 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K6J81_RS17670 | 742767..743045 | + | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| K6J81_RS17675 | 743196..743609 | - | 414 | WP_000049420.1 | VOC family protein | - |
| K6J81_RS19345 | 743684..743800 | - | 117 | WP_086010882.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17680 | 743797..744276 | - | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| K6J81_RS17685 | 744489..745112 | - | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| K6J81_RS17690 | 745318..745743 | - | 426 | WP_000415750.1 | hypothetical protein | - |
| K6J81_RS19350 | 745890..746039 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17695 | 746012..746263 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| K6J81_RS17700 | 746458..746661 | - | 204 | WP_001911580.1 | hypothetical protein | - |
| K6J81_RS17705 | 746918..747304 | - | 387 | WP_000703163.1 | VOC family protein | - |
| K6J81_RS17710 | 747461..747967 | - | 507 | WP_000393074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 730402..773207 | 42805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T38661 WP_000578476.1 NZ_AP024552:742767-743045 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T38661 NZ_AP024552:742767-743045 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT38661 WP_000381183.1 NZ_AP024552:742486-742770 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT38661 NZ_AP024552:742486-742770 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |