38659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 718590..719168 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J81_RS17475 Protein ID WP_001180243.1
Coordinates 718851..719168 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J81_RS17470 Protein ID WP_000557292.1
Coordinates 718590..718832 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J81_RS19280 713990..714106 - 117 WP_001889170.1 hypothetical protein -
K6J81_RS17430 714069..714194 - 126 WP_001944767.1 DUF645 family protein -
K6J81_RS19285 714222..714332 - 111 Protein_654 acetyltransferase -
K6J81_RS19290 714371..714481 - 111 WP_134814058.1 DUF3265 domain-containing protein -
K6J81_RS17435 714478..714795 - 318 WP_001232701.1 HigA family addiction module antitoxin -
K6J81_RS17440 714806..715093 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J81_RS19295 715134..715247 - 114 WP_001894955.1 hypothetical protein -
K6J81_RS17445 715360..715540 - 181 Protein_659 DUF645 family protein -
K6J81_RS17450 715965..716198 - 234 WP_032482776.1 DUF3709 domain-containing protein -
K6J81_RS19300 716219..716412 - 194 Protein_661 hypothetical protein -
K6J81_RS17455 716601..716819 - 219 WP_001917086.1 DUF3709 domain-containing protein -
K6J81_RS19305 716831..717040 - 210 WP_001900246.1 DUF3709 domain-containing protein -
K6J81_RS17460 717129..717782 - 654 WP_000226874.1 hypothetical protein -
K6J81_RS17465 717839..718348 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
K6J81_RS17470 718590..718832 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J81_RS17475 718851..719168 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J81_RS19310 719362..719514 - 153 Protein_668 DUF645 family protein -
K6J81_RS19315 719575..719750 - 176 Protein_669 acetyltransferase -
K6J81_RS17485 719813..720106 - 294 WP_125460920.1 hypothetical protein -
K6J81_RS17490 720253..720600 - 348 WP_000933409.1 hypothetical protein -
K6J81_RS17495 720749..721174 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
K6J81_RS19320 721333..721443 - 111 WP_223804330.1 Tfp pilus assembly protein -
K6J81_RS19325 721433..721495 - 63 Protein_674 DUF645 family protein -
K6J81_RS17505 721846..722382 - 537 WP_000644491.1 nucleotidyltransferase family protein -
K6J81_RS17510 722526..722921 - 396 WP_000046953.1 DUF6404 family protein -
K6J81_RS17515 723098..723217 - 120 WP_001900954.1 DUF645 family protein -
K6J81_RS19330 723340..723483 - 144 Protein_678 acetyltransferase -
K6J81_RS17520 723582..723938 - 357 WP_001094969.1 DUF6404 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 672778..725906 53128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38659 WP_001180243.1 NZ_AP024552:718851-719168 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38659 NZ_AP024552:718851-719168 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38659 WP_000557292.1 NZ_AP024552:718590-718832 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38659 NZ_AP024552:718590-718832 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References