Detailed information of TA system TA038641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 851262..851790
• Replicon: chromosome
• Accession: NZ_AP024550
• Organism: Vibrio cholerae strain IDH-00113

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H9L4R3
• Locus tag: K6J78_RS17505
• Protein ID: WP_000221352.1
• Coordinates: 851262..851552 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H9L4T4
• Locus tag: K6J78_RS17510
• Protein ID: WP_000213183.1
• Coordinates: 851542..851790 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J78_RS18780	846532..846642	+	111	WP_134814058.1	DUF3265 domain-containing protein	-
K6J78_RS18785	846681..846791	+	111	Protein_793	acetyltransferase	-
K6J78_RS17470	846819..846944	+	126	WP_001944767.1	DUF645 family protein	-
K6J78_RS18790	846907..847023	+	117	WP_001889170.1	hypothetical protein	-
K6J78_RS17480	847211..848215	+	1005	WP_000964925.1	LD-carboxypeptidase	-
K6J78_RS17485	848368..848814	+	447	WP_000128977.1	hypothetical protein	-
K6J78_RS17490	848934..849863	+	930	WP_000335802.1	hypothetical protein	-
K6J78_RS18795	849860..849970	+	111	WP_071917832.1	DUF3265 domain-containing protein	-
K6J78_RS17495	849998..850474	+	477	WP_001047180.1	GNAT family N-acetyltransferase	-
K6J78_RS17500	850665..851126	+	462	WP_001911752.1	lipocalin family protein	-
K6J78_RS17505	851262..851552	-	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6J78_RS17510	851542..851790	-	249	WP_000213183.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K6J78_RS17515	852415..854025	+	1611	WP_002041336.1	IS1634-like element ISSpu7 family transposase	-
K6J78_RS17520	854128..854781	+	654	WP_000036957.1	site-specific DNA-methyltransferase	-
K6J78_RS17525	855053..855478	+	426	WP_000415752.1	hypothetical protein	-
K6J78_RS17530	855686..856081	+	396	WP_000649527.1	DUF3465 domain-containing protein	-
K6J78_RS17535	856232..856762	+	531	WP_000415563.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	782725..888585	105860
	-	flank	IS/Tn	-	-	852415..854025	1610
	-	inside	Integron	-	-	835106..888236	53130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.23 Da
• Isoelectric Point: 10.4678

>T38641 WP_000221352.1 NZ_AP024550:c851552-851262 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T38641 NZ_AP024550:c851552-851262 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8937.28 Da
• Isoelectric Point: 4.1079

>AT38641 WP_000213183.1 NZ_AP024550:c851790-851542 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT38641 NZ_AP024550:c851790-851542 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: H9L4R3

Antitoxin

• AlphaFold DB: A0A366A3W8