Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 824354..824892 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K6J78_RS17290 Protein ID WP_000802136.1
Coordinates 824354..824653 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K6J78_RS17295 Protein ID WP_001107719.1
Coordinates 824650..824892 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS18730 820091..820228 + 138 WP_001890145.1 hypothetical protein -
K6J78_RS17250 820289..820471 + 183 WP_000923182.1 DUF645 family protein -
K6J78_RS17255 820671..821144 + 474 WP_001161076.1 GrpB family protein -
K6J78_RS17260 821159..821251 + 93 WP_014378730.1 DUF3265 domain-containing protein -
K6J78_RS17265 821293..821919 + 627 WP_000365424.1 LysE family translocator -
K6J78_RS17270 822042..822740 + 699 WP_001890502.1 hypothetical protein -
K6J78_RS17275 822771..822860 + 90 WP_072606010.1 DUF3265 domain-containing protein -
K6J78_RS17280 823438..823617 + 180 WP_001883058.1 DUF645 family protein -
K6J78_RS17285 823831..824226 + 396 WP_000870857.1 DUF3465 domain-containing protein -
K6J78_RS17290 824354..824653 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J78_RS17295 824650..824892 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K6J78_RS17300 825121..825699 + 579 WP_000110120.1 hypothetical protein -
K6J78_RS17305 825721..825813 + 93 WP_014164112.1 DUF3265 domain-containing protein -
K6J78_RS17310 826237..826920 + 684 WP_000877436.1 hypothetical protein -
K6J78_RS17315 827134..827400 + 267 WP_000937852.1 hypothetical protein -
K6J78_RS17320 827555..828154 + 600 WP_000429495.1 DUF6338 family protein -
K6J78_RS17325 828435..829370 + 936 WP_000051985.1 restriction endonuclease -
K6J78_RS17330 829336..829476 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
- inside Integron - - 787805..830610 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T38639 WP_000802136.1 NZ_AP024550:c824653-824354 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T38639 NZ_AP024550:c824653-824354 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT38639 WP_001107719.1 NZ_AP024550:c824892-824650 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT38639 NZ_AP024550:c824892-824650 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References