38637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 808677..809175 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag K6J78_RS17150 Protein ID WP_000589156.1
Coordinates 808677..808943 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag K6J78_RS17155 Protein ID WP_000643598.1
Coordinates 808930..809175 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17090 803728..803853 + 126 WP_001900195.1 DUF645 family protein -
K6J78_RS17100 804103..804549 + 447 WP_000006157.1 hypothetical protein -
K6J78_RS17105 804697..804966 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
K6J78_RS17110 804959..805237 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J78_RS18690 805288..805405 + 118 Protein_708 DUF3265 domain-containing protein -
K6J78_RS17115 805523..805801 + 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J78_RS18695 806161..806259 + 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J78_RS17125 806459..806560 + 102 WP_001921603.1 hypothetical protein -
K6J78_RS17130 806550..806936 + 387 WP_000703163.1 VOC family protein -
K6J78_RS17135 807131..807382 + 252 WP_001890111.1 TIGR03643 family protein -
K6J78_RS18700 807355..807504 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J78_RS17140 807596..807838 + 243 WP_000107461.1 hypothetical protein -
K6J78_RS17145 808090..808368 + 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J78_RS17150 808677..808943 + 267 WP_000589156.1 BrnT family toxin Toxin
K6J78_RS17155 808930..809175 + 246 WP_000643598.1 hypothetical protein Antitoxin
K6J78_RS17160 809271..810065 + 795 WP_001911581.1 hypothetical protein -
K6J78_RS18705 810062..810178 + 117 WP_086010881.1 DUF3265 domain-containing protein -
K6J78_RS17165 810168..810296 + 129 WP_071908338.1 general secretion pathway protein GspI -
K6J78_RS17170 810357..810539 + 183 WP_000923182.1 DUF645 family protein -
K6J78_RS17175 810755..811759 + 1005 WP_000964920.1 LD-carboxypeptidase -
K6J78_RS17180 811912..812271 + 360 WP_001071541.1 VOC family protein -
K6J78_RS18710 812338..812523 + 186 WP_001999468.1 hypothetical protein -
K6J78_RS18715 812655..812777 + 123 WP_001937972.1 DUF3709 domain-containing protein -
K6J78_RS17190 813045..813551 + 507 WP_000393074.1 hypothetical protein -
K6J78_RS17195 813708..814094 + 387 WP_000703163.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
- inside Integron - - 787805..830610 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T38637 WP_000589156.1 NZ_AP024550:808677-808943 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T38637 NZ_AP024550:808677-808943 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT38637 WP_000643598.1 NZ_AP024550:808930-809175 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT38637 NZ_AP024550:808930-809175 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References