Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 804697..805237 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag K6J78_RS17105 Protein ID WP_000277238.1
Coordinates 804697..804966 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag K6J78_RS17110 Protein ID WP_001258569.1
Coordinates 804959..805237 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17050 799701..799943 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17055 800187..800573 + 387 WP_001015867.1 NUDIX hydrolase -
K6J78_RS17060 800630..800743 + 114 WP_001900214.1 hypothetical protein -
K6J78_RS17065 800752..800973 + 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J78_RS17070 801231..801767 + 537 WP_000469482.1 GNAT family protein -
K6J78_RS17075 801958..802419 + 462 WP_001903091.1 lipocalin family protein -
K6J78_RS18685 802484..802552 + 69 Protein_701 acetyltransferase -
K6J78_RS17080 802569..803066 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J78_RS17085 803063..803335 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J78_RS17090 803728..803853 + 126 WP_001900195.1 DUF645 family protein -
K6J78_RS17100 804103..804549 + 447 WP_000006157.1 hypothetical protein -
K6J78_RS17105 804697..804966 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J78_RS17110 804959..805237 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J78_RS18690 805288..805405 + 118 Protein_708 DUF3265 domain-containing protein -
K6J78_RS17115 805523..805801 + 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J78_RS18695 806161..806259 + 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J78_RS17125 806459..806560 + 102 WP_001921603.1 hypothetical protein -
K6J78_RS17130 806550..806936 + 387 WP_000703163.1 VOC family protein -
K6J78_RS17135 807131..807382 + 252 WP_001890111.1 TIGR03643 family protein -
K6J78_RS18700 807355..807504 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J78_RS17140 807596..807838 + 243 WP_000107461.1 hypothetical protein -
K6J78_RS17145 808090..808368 + 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J78_RS17150 808677..808943 + 267 WP_000589156.1 BrnT family toxin -
K6J78_RS17155 808930..809175 + 246 WP_000643598.1 hypothetical protein -
K6J78_RS17160 809271..810065 + 795 WP_001911581.1 hypothetical protein -
K6J78_RS18705 810062..810178 + 117 WP_086010881.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
- inside Integron - - 787805..830610 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T38636 WP_000277238.1 NZ_AP024550:c804966-804697 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T38636 NZ_AP024550:c804966-804697 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT38636 WP_001258569.1 NZ_AP024550:c805237-804959 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT38636 NZ_AP024550:c805237-804959 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References