38635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 802569..803335 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J78_RS17080 Protein ID WP_000982260.1
Coordinates 802569..803066 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J78_RS17085 Protein ID WP_000246253.1
Coordinates 803063..803335 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17035 798011..798715 + 705 WP_000087610.1 HNH endonuclease -
K6J78_RS17040 798873..799211 + 339 WP_000713853.1 hypothetical protein -
K6J78_RS17045 799365..799682 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17050 799701..799943 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17055 800187..800573 + 387 WP_001015867.1 NUDIX hydrolase -
K6J78_RS17060 800630..800743 + 114 WP_001900214.1 hypothetical protein -
K6J78_RS17065 800752..800973 + 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J78_RS17070 801231..801767 + 537 WP_000469482.1 GNAT family protein -
K6J78_RS17075 801958..802419 + 462 WP_001903091.1 lipocalin family protein -
K6J78_RS18685 802484..802552 + 69 Protein_701 acetyltransferase -
K6J78_RS17080 802569..803066 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K6J78_RS17085 803063..803335 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K6J78_RS17090 803728..803853 + 126 WP_001900195.1 DUF645 family protein -
K6J78_RS17100 804103..804549 + 447 WP_000006157.1 hypothetical protein -
K6J78_RS17105 804697..804966 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
K6J78_RS17110 804959..805237 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J78_RS18690 805288..805405 + 118 Protein_708 DUF3265 domain-containing protein -
K6J78_RS17115 805523..805801 + 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J78_RS18695 806161..806259 + 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J78_RS17125 806459..806560 + 102 WP_001921603.1 hypothetical protein -
K6J78_RS17130 806550..806936 + 387 WP_000703163.1 VOC family protein -
K6J78_RS17135 807131..807382 + 252 WP_001890111.1 TIGR03643 family protein -
K6J78_RS18700 807355..807504 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J78_RS17140 807596..807838 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
- inside Integron - - 787805..830610 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38635 WP_000982260.1 NZ_AP024550:c803066-802569 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38635 NZ_AP024550:c803066-802569 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38635 WP_000246253.1 NZ_AP024550:c803335-803063 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38635 NZ_AP024550:c803335-803063 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References