Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 799365..799943 | Replicon | chromosome |
| Accession | NZ_AP024550 | ||
| Organism | Vibrio cholerae strain IDH-00113 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | K6J78_RS17045 | Protein ID | WP_001180243.1 |
| Coordinates | 799365..799682 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | K6J78_RS17050 | Protein ID | WP_000557292.1 |
| Coordinates | 799701..799943 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J78_RS17015 | 794889..795071 | + | 183 | WP_000923340.1 | DUF645 family protein | - |
| K6J78_RS18680 | 795191..795253 | + | 63 | Protein_688 | acetyltransferase | - |
| K6J78_RS17020 | 795425..795607 | + | 183 | WP_000923153.1 | DUF645 family protein | - |
| K6J78_RS17025 | 795802..796479 | + | 678 | WP_000254617.1 | HNH endonuclease signature motif containing protein | - |
| K6J78_RS17030 | 796641..797849 | + | 1209 | WP_000272282.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| K6J78_RS17035 | 798011..798715 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
| K6J78_RS17040 | 798873..799211 | + | 339 | WP_000713853.1 | hypothetical protein | - |
| K6J78_RS17045 | 799365..799682 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6J78_RS17050 | 799701..799943 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6J78_RS17055 | 800187..800573 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| K6J78_RS17060 | 800630..800743 | + | 114 | WP_001900214.1 | hypothetical protein | - |
| K6J78_RS17065 | 800752..800973 | + | 222 | WP_032467793.1 | DUF1289 domain-containing protein | - |
| K6J78_RS17070 | 801231..801767 | + | 537 | WP_000469482.1 | GNAT family protein | - |
| K6J78_RS17075 | 801958..802419 | + | 462 | WP_001903091.1 | lipocalin family protein | - |
| K6J78_RS18685 | 802484..802552 | + | 69 | Protein_701 | acetyltransferase | - |
| K6J78_RS17080 | 802569..803066 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| K6J78_RS17085 | 803063..803335 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| K6J78_RS17090 | 803728..803853 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
| K6J78_RS17100 | 804103..804549 | + | 447 | WP_000006157.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 782725..888585 | 105860 | |
| - | inside | Integron | - | - | 787805..830610 | 42805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T38634 WP_001180243.1 NZ_AP024550:c799682-799365 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T38634 NZ_AP024550:c799682-799365 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT38634 WP_000557292.1 NZ_AP024550:c799943-799701 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT38634 NZ_AP024550:c799943-799701 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |