Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2462424..2463076 Replicon chromosome
Accession NZ_AP024546
Organism Lysobacter helvus strain JCM32364

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LYSHEL_RS11935 Protein ID WP_213437897.1
Coordinates 2462873..2463076 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LYSHEL_RS11930 Protein ID WP_213434256.1
Coordinates 2462424..2462858 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSHEL_RS11910 (LYSHEL_23490) 2457640..2458806 + 1167 WP_213434253.1 glycosyltransferase family 4 protein -
LYSHEL_RS11915 (LYSHEL_23500) 2458811..2459572 + 762 WP_213434254.1 YdcF family protein -
LYSHEL_RS11920 (LYSHEL_23510) 2459777..2460850 + 1074 WP_244858535.1 polysaccharide biosynthesis/export family protein -
LYSHEL_RS11925 (LYSHEL_23520) 2460992..2462416 + 1425 WP_213434255.1 DNA repair protein RadA -
LYSHEL_RS11930 (LYSHEL_23530) 2462424..2462858 - 435 WP_213434256.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LYSHEL_RS11935 (LYSHEL_23540) 2462873..2463076 - 204 WP_213437897.1 hypothetical protein Toxin
LYSHEL_RS11940 (LYSHEL_23550) 2463222..2464793 - 1572 WP_213434257.1 DHA2 family efflux MFS transporter permease subunit -
LYSHEL_RS11945 (LYSHEL_23560) 2464812..2465990 - 1179 WP_213434258.1 efflux RND transporter periplasmic adaptor subunit -
LYSHEL_RS11950 (LYSHEL_23570) 2466006..2467463 - 1458 WP_213434259.1 efflux transporter outer membrane subunit -
LYSHEL_RS11955 (LYSHEL_23580) 2467465..2467908 - 444 WP_213434260.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7749.01 Da        Isoelectric Point: 11.1552

>T38614 WP_213437897.1 NZ_AP024546:c2463076-2462873 [Lysobacter helvus]
MDAGFHGAMDMKQCEFRRWLALRGALFKEGSKHTRVYYRGRQSTLPRHPAHEIGEALRKAIIRQPGL

Download         Length: 204 bp

>T38614 NZ_AP024546:c2463076-2462873 [Lysobacter helvus]
ATGGACGCCGGTTTCCACGGCGCCATGGACATGAAGCAGTGCGAATTCCGCCGGTGGCTCGCATTGCGCGGCGCGTTGTT
CAAGGAAGGCAGCAAGCACACGCGCGTGTACTACCGCGGCCGGCAGAGCACCCTGCCCCGGCATCCGGCGCACGAGATCG
GTGAAGCGCTGCGCAAGGCGATCATCCGCCAACCCGGCCTCTGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16275.75 Da        Isoelectric Point: 7.2054

>AT38614 WP_213434256.1 NZ_AP024546:c2462858-2462424 [Lysobacter helvus]
MLVYPVTIERDGKGWFVRFDDIPEALTSGRSRAHALSMAQDALESAMEFYFQDRRPVPLPGKAKPGQDTVELPASLSAKV
LLLNEMLVQGITPAELARRLDTTPQSVQRIIDLDHVTKIDTIAQAFRVMDRRLDFQVKRWPQSA

Download         Length: 435 bp

>AT38614 NZ_AP024546:c2462858-2462424 [Lysobacter helvus]
ATGCTGGTCTACCCCGTCACGATCGAACGCGATGGCAAGGGATGGTTCGTGCGTTTCGACGACATCCCCGAAGCGCTCAC
CTCCGGGCGTTCGCGCGCGCATGCGCTGTCGATGGCGCAGGACGCGCTCGAGAGCGCGATGGAGTTCTACTTCCAGGATC
GCCGTCCGGTGCCGTTGCCGGGCAAGGCGAAGCCGGGCCAGGACACGGTCGAACTGCCCGCCTCGCTCAGCGCCAAGGTG
CTGCTGCTCAACGAAATGCTGGTGCAGGGCATCACGCCGGCGGAACTCGCCCGCCGCCTCGACACCACGCCGCAATCCGT
GCAGCGCATCATCGACCTGGACCACGTCACCAAGATCGACACCATCGCGCAGGCGTTCCGCGTGATGGACCGGCGGCTGG
ATTTCCAGGTGAAGCGTTGGCCGCAATCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References